Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 9/20 | 0.56 |
| ▸ | MAPK9 | P45984 | 8/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 3/20 | 0.46 |
| ▸ | CSF1R | P07333 | 3/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.44 |
| ▸ | INSR | P06213 | 2/20 | 0.44 |
| ▸ | IGF1R | P08069 | 2/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1559161 | 0.90 | MAPK9 (0.51) | MAPK10MAPK9MAPK1MAPK3F10 | |
| SCHEMBL1559117 | 0.87 | MAPK10 (0.53) | MAPK10MAPK9MAPK1MAPK3F10 | |
| SCHEMBL1558002 | 0.86 | MAPK10 (0.54) | MAPK10MAPK9MAPK1MAPK3F10 | |
| SCHEMBL12312041 | 0.83 | EGFR (0.59) | MAPK10MAPK9MAPK1CSF1REGFR | |
| SCHEMBL4096101 | 0.83 | EGFR (0.54) | MAPK10MAPK9MAPK1CSF1REGFR | |
| SCHEMBL13849428 | 0.82 | EGFR (0.53) | MAPK10MAPK9MAPK1CSF1REGFR | |
| SCHEMBL12571178 | 0.80 | EGFR (0.51) | MAPK10MAPK9MAPK1CSF1REGFR | |
| SCHEMBL1293075 | 0.80 | ALK (0.49) | MAPK10MAPK9MAPK1CSF1REGFR | |
| SCHEMBL690645 | 0.78 | MAPK10 (0.49) | MAPK10MAPK9MAPK1MAPK3CSF1R | |
| SCHEMBL691599 | 0.77 | MAPK10 (0.50) | MAPK10MAPK9MAPK1MAPK3CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8569298-B2 | Pyridine compounds | ASTRAZENECA AB (SE) | 2013-10-29 | — | — | US | disclosed |
| US-20110166139-A1 | PYRIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166139-A1 | PYRIDINE COMPOUNDS | PTK2, PTK2B, PFKP | MAPK10 301/4885MAPK9 217/4885MAPK1 149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.