SCHEMBL12414867

SCHEMBL12414867

CCCCN1/C(=C/C=C2\CCC(/C=C/C3=[N+](CCCC)c4ccc(I)cc4C3(C)C)=C2Cl)C(C)(C)c2cc(I)ccc21

nearest known ligand 0.54

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PRMT1 Q99873 10/20 0.54
PRMT5 O14744 2/20 0.54
PRMT8 Q9NR22 2/20 0.54
CARM1 Q86X55 1/20 0.54
PTPN1 P18031 1/20 0.43
FOLH1 Q04609 2/20 0.36
HTR1A P08908 1/20 0.33
FOLR1 P15328 3/20 0.33
APP P05067 2/20 0.33
MAPT P10636 1/20 0.33
BLM P54132 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12414895 0.96 PRMT1 (0.54) PRMT1PRMT5PRMT8CARM1PTPN1
SCHEMBL12414855 0.96 PRMT1 (0.50) PRMT1PRMT5PRMT8CARM1PTPN1
SCHEMBL18256957 0.92 PTPN1 (0.54) PRMT1PRMT5PRMT8CARM1PTPN1
SCHEMBL24305737 0.92 PRMT1 (0.57) PRMT1PRMT5PRMT8CARM1PTPN1
SCHEMBL12414866 0.92 PRMT1 (0.45) PRMT1PRMT5PRMT8CARM1PTPN1
SCHEMBL24384627 0.92 PRMT1 (0.55) PRMT1PRMT5PRMT8CARM1PTPN1
SCHEMBL12414865 0.91 PRMT1 (0.67) PRMT1PRMT5PRMT8CARM1PTPN1
SCHEMBL12414881 0.90 PRMT1 (0.47) PRMT1PRMT5PRMT8CARM1PTPN1
SCHEMBL12414874 0.90 PRMT1 (0.47) PRMT1PRMT5PRMT8CARM1PTPN1
SCHEMBL12414876 0.90 PTPN1 (0.56) PRMT1PRMT5PRMT8CARM1PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110165518-A1 LITHOGRAPHIC PRINTING PLATE PRECURSOR AGFA GRAPHICS NV (BE) 2011-07-07 US disclosed