SCHEMBL12414874

SCHEMBL12414874

COCCCN1/C(=C/C=C2\CCC(/C=C/C3=[N+](CCCOC)c4ccc(I)cc4C3(C)C)=C2Cl)C(C)(C)c2cc(I)ccc21

nearest known ligand 0.47

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PRMT1 Q99873 10/20 0.47
PRMT5 O14744 2/20 0.44
PRMT8 Q9NR22 2/20 0.44
CARM1 Q86X55 1/20 0.44
PTPN1 P18031 1/20 0.41
FOLH1 Q04609 3/20 0.38
HTR1A P08908 1/20 0.35
FOLR1 P15328 4/20 0.33
EGFR P00533 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12414904 0.96 PRMT1 (0.46) PRMT1PRMT5PRMT8CARM1PTPN1
SCHEMBL12155001 0.92 PRMT1 (0.47) PRMT1PRMT5PRMT8CARM1PTPN1
SCHEMBL12414872 0.91 PRMT1 (0.54) PRMT1PRMT5PRMT8CARM1PTPN1
SCHEMBL21132747 0.91 PRMT1 (0.47) PRMT1PRMT5PRMT8CARM1PTPN1
SCHEMBL12414867 0.90 PRMT1 (0.54) PRMT1PRMT5PRMT8CARM1PTPN1
SCHEMBL12414855 0.90 PRMT1 (0.50) PRMT1PRMT5PRMT8CARM1PTPN1
SCHEMBL20381943 0.88 PRMT1 (0.47) PRMT1PRMT5PRMT8CARM1PTPN1
SCHEMBL12414881 0.88 PRMT1 (0.47) PRMT1PRMT5PRMT8CARM1PTPN1
SCHEMBL12414902 0.88 PRMT1 (0.54) PRMT1PRMT5PRMT8CARM1PTPN1
SCHEMBL25837251 0.87 PRMT1 (0.45) PRMT1PRMT5PRMT8CARM1PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110165518-A1 LITHOGRAPHIC PRINTING PLATE PRECURSOR AGFA GRAPHICS NV (BE) 2011-07-07 US disclosed