SCHEMBL12414904

SCHEMBL12414904

COCCCN1/C(=C/C=C2\CCCC(/C=C/C3=[N+](CCCOC)c4ccc(I)cc4C3(C)C)=C2Cl)C(C)(C)c2cc(I)ccc21

nearest known ligand 0.46

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PRMT1 Q99873 8/20 0.46
PRMT5 O14744 1/20 0.43
CARM1 Q86X55 1/20 0.43
PRMT8 Q9NR22 1/20 0.43
PTPN1 P18031 1/20 0.41
FOLH1 Q04609 4/20 0.41
HTR1A P08908 1/20 0.38
FOLR1 P15328 5/20 0.36
APP P05067 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12414874 0.96 PRMT1 (0.47) PRMT1PRMT5CARM1PRMT8PTPN1
SCHEMBL20381943 0.92 PRMT1 (0.47) PRMT1PRMT5CARM1PRMT8PTPN1
SCHEMBL12414902 0.91 PRMT1 (0.54) PRMT1PRMT5CARM1PRMT8PTPN1
SCHEMBL12414895 0.90 PRMT1 (0.54) PRMT1PRMT5CARM1PRMT8PTPN1
SCHEMBL12155001 0.88 PRMT1 (0.47) PRMT1PRMT5CARM1PRMT8PTPN1
SCHEMBL25863685 0.88 PRMT1 (0.59) PRMT1PRMT5CARM1PRMT8PTPN1
SCHEMBL12414872 0.88 PRMT1 (0.54) PRMT1PRMT5CARM1PRMT8PTPN1
SCHEMBL21132747 0.88 PRMT1 (0.47) PRMT1PRMT5CARM1PRMT8PTPN1
SCHEMBL12414867 0.87 PRMT1 (0.54) PRMT1PRMT5CARM1PRMT8PTPN1
SCHEMBL18894227 0.86 PTPN1 (0.57) PRMT1PRMT5CARM1PRMT8PTPN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110165518-A1 LITHOGRAPHIC PRINTING PLATE PRECURSOR AGFA GRAPHICS NV (BE) 2011-07-07 US disclosed