SCHEMBL12417166

SCHEMBL12417166

CNc1cc(C(c2ccc(O)c(NC(=O)c3ccc(Oc4ccc(C(C)=O)cc4)cc3)c2)(C(F)(F)F)C(F)(F)F)ccc1O

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ESRRA P11474 1/20 0.47
MAPT P10636 3/20 0.47
KDM4E B2RXH2 2/20 0.47
MAPK1 P28482 1/20 0.43
KCNMA1 Q12791 3/20 0.42
HPGD P15428 2/20 0.41
RAB9A P51151 1/20 0.41
KMT2A Q03164 2/20 0.40
MEN1 O00255 1/20 0.40
RXFP1 Q9HBX9 1/20 0.39
HTT P42858 2/20 0.39
TSHR P16473 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
AKT1 P31749 1/20 0.38
HDAC1 Q13547 2/20 0.38
LIPE Q05469 5/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13878424 0.95 ESRRA (0.43) ESRRAMAPTKDM4EMAPK1KCNMA1
SCHEMBL13955809 0.94 ESRRA (0.44) ESRRAMAPTKDM4EMAPK1KCNMA1
SCHEMBL13955797 0.94 MAPT (0.47) ESRRAMAPTKDM4EMAPK1KCNMA1
SCHEMBL13955813 0.92 ESRRA (0.48) ESRRAMAPTKDM4EMAPK1KCNMA1
SCHEMBL677917 0.92 KCNMA1 (0.46) MAPTKDM4EKCNMA1KMT2AMEN1
SCHEMBL14094885 0.90 MAPT (0.48) ESRRAMAPTKDM4EMAPK1KCNMA1
SCHEMBL676664 0.90 HDAC1 (0.47) KCNMA1KMT2AMEN1RXFP1HDAC1
SCHEMBL13742426 0.89 MAPT (0.45) MAPTKDM4EMAPK1KCNMA1HPGD
SCHEMBL12977115 0.89 ESRRA (0.44) ESRRAMAPTKDM4EMAPK1HPGD
SCHEMBL13955815 0.88 ESRRA (0.44) ESRRAMAPTKDM4EMAPK1KCNMA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230303480-A1 Polybenzoxazole, Polyamide, Polyamide Solution, Insulating Material for High-Frequency Electronic Component, High-Frequency Electronic Component, High-Frequency Equipment, Insulating Material for Producing High-Frequency Electronic Component, Method for Producing Polyamide, Method for Producing Polybenzoxazole, Method for Producing Insulating Material for High-Frequency Electronic Component, and Diamine or Salt Thereof CENTRAL GLASS COMPANY, LIMITED (JP) 2023-09-28 US disclosed
US-20230287178-A1 Fluorinated Diamine or Salt Thereof, Method for Producing Fluorinated Diamine or Salt Thereof, Polyamide, Method for Producing Polyamide, Polyamide Solution, Cyclized Polyamide, Method for Producing Cyclized Polyamide, Insulation for High-Frequency Electronic Component, Method for Producing Insulation for High-Frequency Electronic Component, High-Frequency Electronic Component, High-Frequency Appliance, and Insulating Material for Producing High-Frequency Electronic Component CENTRAL GLASS COMPANY, LIMITED (JP) 2023-09-14 US disclosed
US-8703367-B2 Positive photosensitive resin composition CHEIL INDUSTRIES INC. (KR) 2014-04-22 US disclosed
US-8703367-B2 Positive photosensitive resin composition CHEIL INDUSTRIES INC. (KR) 2014-04-22 US disclosed
US-20110171578-A1 Positive Photosensitive Resin Composition CHEIL INDUSTRIES INC. (KR) 2011-07-14 US disclosed
US-20090004444-A1 Novel Photosensitive Resin Compositions FUJIFILM ELECTRONIC MATERIALS U.S.A., INC. (US) 2009-01-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230303480-A1 Polybenzoxazole, Polyamide, Polyamide Solution, Insulating Material for High-Frequency Electronic Component, High-Frequency Electronic Component, High-Frequency Equipment, Insulating Material for Producing High-Frequency Electronic Component, Method for Producing Polyamide, Method for Producing Polybenzoxazole, Method for Producing Insulating Material for High-Frequency Electronic Component, and Diamine or Salt Thereof PUF60, TET1, PBRM1 ESRRA 3174/4885MAPT 3125/4885KDM4E 1909/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.