SCHEMBL677917

SCHEMBL677917

CNc1cc(C(c2ccc(O)c(NC(=O)c3ccc(C(c4ccc(C(C)=O)cc4)(C(F)(F)F)C(F)(F)F)cc3)c2)(C(F)(F)F)C(F)(F)F)ccc1O

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
KCNMA1 Q12791 5/20 0.46
KMT2A Q03164 2/20 0.45
MEN1 O00255 1/20 0.45
RXFP1 Q9HBX9 1/20 0.42
AKT1 P31749 1/20 0.41
HDAC1 Q13547 4/20 0.41
HDAC2 Q92769 2/20 0.39
KDM4E B2RXH2 2/20 0.38
MAPT P10636 1/20 0.38
HTT P42858 1/20 0.38
HPSE Q9Y251 1/20 0.38
GAA P10253 1/20 0.37
CHRNA7 P36544 1/20 0.37
TMPRSS4 Q9NRS4 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL676664 0.95 HDAC1 (0.47) KCNMA1KMT2AMEN1RXFP1HDAC1
SCHEMBL12417166 0.92 ESRRA (0.47) KCNMA1KMT2AMEN1RXFP1AKT1
SCHEMBL13955812 0.91 HDAC1 (0.47) KCNMA1KMT2AMEN1AKT1HDAC1
SCHEMBL677965 0.90 KCNMA1 (0.45) KCNMA1KMT2AMEN1RXFP1HDAC1
SCHEMBL676652 0.89 HDAC1 (0.46) KCNMA1KMT2AMEN1RXFP1AKT1
SCHEMBL14094886 0.88 KCNMA1 (0.62) KCNMA1KMT2AMEN1AKT1HDAC1
SCHEMBL13955816 0.88 KCNMA1 (0.57) KCNMA1KMT2AMEN1AKT1HDAC1
SCHEMBL13878424 0.88 ESRRA (0.43) KCNMA1KMT2AMEN1RXFP1AKT1
SCHEMBL12376417 0.87 MEN1 (0.42) KCNMA1KMT2AMEN1RXFP1AKT1
SCHEMBL13955814 0.86 KCNMA1 (0.45) KCNMA1KMT2AMEN1AKT1HDAC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7906213-B2 Epoxy resin curable composition for prepreg ADEKA CORPORATION (JP) 2011-03-15 US disclosed
US-20090030147-A1 Epoxy Resin Curable Composition For Prepreg ADEKA CORPORATION (JP) 2009-01-29 US disclosed