Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | EPHX2 | P34913 | 14/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20999491 | 0.83 | KDM4E (0.63) | KDM4EHTTEPHX2KMT2AMEN1 | |
| SCHEMBL17702625 | 0.83 | KMT2A (0.70) | KDM4EHTTEPHX2KMT2AMEN1 | |
| SCHEMBL16365921 | 0.82 | KDM4E (0.76) | KDM4EHTTEPHX2KMT2AMEN1 | |
| SCHEMBL27004615 | 0.79 | HTT (0.62) | KDM4EHTTEPHX2KMT2AMEN1 | |
| SCHEMBL25984015 | 0.79 | KDM4E (0.50) | KDM4EHTTEPHX2KMT2AMEN1 | |
| SCHEMBL11513574 | 0.79 | ALDH1A1 (0.57) | KDM4EHTTEPHX2KMT2AMEN1 | |
| SCHEMBL17703651 | 0.79 | KDM4E (0.57) | KDM4EHTTEPHX2KMT2AMEN1 | |
| SCHEMBL17755397 | 0.79 | HTT (0.57) | KDM4EHTTEPHX2KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL11516217 | 0.78 | ALDH1A1 (0.59) | KDM4EHTTEPHX2KMT2AMEN1 | |
| SCHEMBL19426816 | 0.78 | KDM4E (0.59) | KDM4EHTTEPHX2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8431529-B2 | Bi-dentate compounds as kinase inhibitors | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2013-04-30 | — | — | US | disclosed |
| US-8431529-B2 | Bi-dentate compounds as kinase inhibitors | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2013-04-30 | — | — | US | disclosed |
| US-20110172164-A1 | BI-DENTATE COMPOUNDS AS KINASE INHIBITORS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-07-14 | — | — | US | disclosed |
| US-20110172164-A1 | BI-DENTATE COMPOUNDS AS KINASE INHIBITORS | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2011-07-14 | — | — | US | disclosed |
| US-7919581-B2 | Bi-dentate compounds as kinase inhibitors | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-04-05 | — | — | US | disclosed |
| US-7919581-B2 | Bi-dentate compounds as kinase inhibitors | BURNHAM INSTITUTE FOR MEDICAL RESEARCH (US) | 2011-04-05 | — | — | US | disclosed |
| US-20090054348-A1 | BI-DENTATE COMPOUNDS AS KINASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-02-26 | — | — | US | disclosed |
| US-20090054348-A1 | BI-DENTATE COMPOUNDS AS KINASE INHIBITORS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-02-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172164-A1 | BI-DENTATE COMPOUNDS AS KINASE INHIBITORS | MAP2K2, MAP2K7, MAP2K1 | KDM4E 3572/4885HTT 2530/4885EPHX2 538/4885 |
| US-20090054348-A1 | BI-DENTATE COMPOUNDS AS KINASE INHIBITORS | MAP2K2, MAP2K1, MAP2K7 | KDM4E 3505/4885HTT 2463/4885EPHX2 347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.