Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.57 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 7/20 | 0.40 |
| ▸ | DRD3 | P35462 | 5/20 | 0.40 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12509444 | 0.78 | HSD11B1 (0.62) | HSD11B1CNR2DRD4DRD3DRD2 | |
| SCHEMBL25427364 | 0.77 | HSD11B1 (0.50) | HSD11B1CNR2DRD4DRD3DRD2 | |
| SCHEMBL30509707 | 0.77 | HSD11B1 (0.50) | HSD11B1CNR2DRD4DRD3DRD2 | |
| SCHEMBL1814618 | 0.75 | HSD11B1 (0.66) | HSD11B1CNR2DRD4DRD3DRD2 | |
| SCHEMBL1824140 | 0.73 | HSD11B1 (1.00) | HSD11B1DRD4DRD3DRD2HTR7 | |
| SCHEMBL1813724 | 0.73 | HSD11B1 (1.00) | HSD11B1CNR2DRD4DRD3DRD2 | |
| SCHEMBL12422658 | 0.73 | HSD11B1 (0.44) | HSD11B1CNR2DRD4DRD3DRD2 | |
| Hydrochloric Acid SCHEMBL1816561 | 0.69 | HSD11B1 (0.45) | HSD11B1CNR2AXLGPR84HTR2A | |
| SCHEMBL1812773 | 0.69 | HSD11B1 (0.44) | HSD11B1CNR2DRD4DRD3DRD2 | |
| SCHEMBL25774687 | 0.68 | HSD11B1 (0.45) | HSD11B1CNR2DRD4DRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8486964-B2 | Fused pyrrolidino-cyclopropane derivatives as selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors | MERCK PATENT GMBH (DE) | 2013-07-16 | — | — | US | disclosed |
| US-20110172265-A1 | Fused pyrrolidino-cyclopropane derivatives as selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172265-A1 | Fused pyrrolidino-cyclopropane derivatives as selective 11-beta-hydroxysteroid dehydrogenase type 1 inhibitors | HSD11B1, HSD17B1, HSD11B2 | HSD11B1 1/4885CNR2 2989/4885DRD4 1530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.