Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 11/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.43 |
| ▸ | ITGAV | P06756 | 3/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4186497 | 0.88 | KCNA5 (0.55) | KCNA5KCNH2ITGB3ITGAVITGA2B | |
| SCHEMBL1243112 | 0.86 | KCNA5 (0.51) | KCNA5KCNH2ITGB3ITGAVEPHX2 | |
| SCHEMBL1243109 | 0.86 | KCNA5 (0.51) | KCNA5KCNH2ITGB3ITGAVEPHX2 | |
| SCHEMBL1240848 | 0.86 | NOTUM (0.53) | KCNA5KCNH2LMNA | |
| SCHEMBL9902165 | 0.85 | KCNA5 (0.58) | KCNA5KCNH2SMN1; SMN2 | |
| SCHEMBL9901968 | 0.85 | KCNA5 (0.58) | KCNA5KCNH2SMN1; SMN2 | |
| SCHEMBL1242166 | 0.85 | KCNA5 (0.50) | KCNA5KCNH2EPHX2LMNAHPGD | |
| SCHEMBL1242164 | 0.85 | KCNA5 (0.50) | KCNA5KCNH2EPHX2LMNAHPGD | |
| SCHEMBL1242933 | 0.84 | KCNA5 (0.52) | KCNA5KCNH2EPHX2LMNAHPGD | |
| SCHEMBL1243149 | 0.84 | CYP1A2 (0.52) | KCNA5KCNH2EPHX2LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879839-B2 | For treatment and prevention of cardiac arrhythmias; (+-)-2-Morpholin-4-yl-2-phenyl-1,1-dipyridin-3-yl-ethanol; (+-)-2-[(2-methoxyethyl)(methyl)amino]-2-phenyl-1,1-dipyridin-3-ylethanol | MERCK SHARP & DOHME CORP. (US) | 2011-02-01 | — | — | US | disclosed |