Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 9/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.44 |
| ▸ | ITGAV | P06756 | 3/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1242273 | 0.88 | KCNA5 (0.56) | KCNA5KCNH2EPHX2LMNAHPGD | |
| SCHEMBL1242933 | 0.87 | KCNA5 (0.52) | KCNA5KCNH2EPHX2LMNAHPGD | |
| SCHEMBL1243357 | 0.87 | KCNA5 (0.52) | KCNA5KCNH2EPHX2LMNAHPGD | |
| SCHEMBL1243109 | 0.86 | KCNA5 (0.51) | KCNA5KCNH2EPHX2LMNAHPGD | |
| SCHEMBL1243112 | 0.86 | KCNA5 (0.51) | KCNA5KCNH2EPHX2LMNAHPGD | |
| SCHEMBL9902165 | 0.85 | KCNA5 (0.58) | KCNA5KCNH2SMN1; SMN2 | |
| SCHEMBL9901968 | 0.85 | KCNA5 (0.58) | KCNA5KCNH2SMN1; SMN2 | |
| SCHEMBL1242166 | 0.85 | KCNA5 (0.50) | KCNA5KCNH2EPHX2LMNAHPGD | |
| SCHEMBL1242364 | 0.85 | KCNA5 (0.53) | KCNA5KCNH2EPHX2LMNAHPGD | |
| SCHEMBL1242944 | 0.85 | KCNA5 (0.53) | KCNA5KCNH2EPHX2LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781635-A4 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO INC (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1781635-A2 | POTASSIUM CHANNEL INHIBITORS | Merck & Co., Inc. (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006015159-A2 | POTASSIUM CHANNEL INHIBITORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | disclosed |