Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 11/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9901968 | 1.00 | KCNA5 (0.58) | KCNA5KCNH2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4577826 | 0.89 | KCNA5 (0.53) | KCNA5KCNH2MEN1KMT2A | |
| SCHEMBL4580891 | 0.89 | POLB (0.48) | KCNA5KCNH2 | |
| SCHEMBL1240787 | 0.87 | KCNA5 (0.53) | KCNA5KCNH2MEN1KMT2A | |
| SCHEMBL1240785 | 0.87 | KCNA5 (0.53) | KCNA5KCNH2MEN1KMT2A | |
| SCHEMBL4186497 | 0.85 | KCNA5 (0.55) | KCNA5KCNH2SMN1; SMN2 | |
| SCHEMBL1242273 | 0.85 | KCNA5 (0.56) | KCNA5KCNH2SMN1; SMN2 | |
| SCHEMBL1243109 | 0.84 | KCNA5 (0.51) | KCNA5KCNH2SMN1; SMN2 | |
| SCHEMBL1243112 | 0.84 | KCNA5 (0.51) | KCNA5KCNH2SMN1; SMN2 | |
| SCHEMBL1242161 | 0.84 | KCNA5 (0.51) | KCNA5KCNH2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781635-B1 | POTASSIUM CHANNEL INHIBITORS | MERCK SHARP & DOHME (US) | 2012-06-13 | — | — | EP | disclosed |