Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 17/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10196403 | 1.00 | CETP (0.43) | CETPLMNAGAAHTTCYP1A2 | |
| SCHEMBL663765 | 0.88 | CETP (0.47) | CETP | |
| SCHEMBL16359992 | 0.85 | CETP (0.34) | CETPLMNAGAAHTTCYP1A2 | |
| SCHEMBL10196417 | 0.85 | CETP (0.34) | CETPLMNAGAAHTTCYP1A2 | |
| SCHEMBL663475 | 0.83 | CYP1A2 (0.52) | LMNAGAAHTTCYP1A2CYP2C9 | |
| SCHEMBL12423364 | 0.79 | CETP (0.45) | CETPLMNAGAAHTTCYP1A2 | |
| SCHEMBL10196397 | 0.79 | CETP (0.45) | CETPLMNAGAAHTTCYP1A2 | |
| SCHEMBL10196449 | 0.78 | CETP (0.40) | CETP | |
| SCHEMBL16258486 | 0.78 | CETP (0.40) | CETP | |
| SCHEMBL16363068 | 0.77 | CETP (0.41) | CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536733-B1 | TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION | BOEHRINGER INGELHEIM INT (DE) | 2014-11-26 | — | — | EP | disclosed |
| WO-2011101424-A1 | TRICYCLIC PYRIDINE DERIVATIVES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PREPARATION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-08-25 | — | — | WO | disclosed |