Taurocholic Acid

Taurocholic Acid

SCHEMBL124237

C[C@H](CCC(=O)NCCS(=O)(=O)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C.[NaH]

nearest known ligand 0.98

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPBAR1 Q8TDU6 7/20 0.98
SLC10A2 Q12908 4/20 0.98
SLC10A1 Q14973 3/20 0.98
TSHR P16473 1/20 0.84
RAB9A P51151 1/20 0.84
LMNA P02545 1/20 0.84
BLM P54132 1/20 0.84
NR1H4 Q96RI1 3/20 0.80
ABCC4 O15439 2/20 0.80
ABCB11 O95342 2/20 0.80
PLA2G1B P04054 1/20 0.80
ENPP2 Q13822 1/20 0.80
KMT2A Q03164 2/20 0.74
CA1 P00915 2/20 0.70
CA2 P00918 2/20 0.70
CYP3A4 P08684 3/20 0.70
PDE3A Q14432 1/20 0.70
MEN1 O00255 1/20 0.69
SLCO1B3 Q9NPD5 1/20 0.69
SLCO1B1 Q9Y6L6 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Taurocholic Acid SCHEMBL9224412 1.00 GPBAR1 (0.98) GPBAR1SLC10A2SLC10A1TSHRRAB9A
Taurocholic Acid SCHEMBL9900941 0.99 GPBAR1 (0.97) GPBAR1SLC10A2SLC10A1TSHRRAB9A
Taurocholic Acid SCHEMBL9900942 0.99 GPBAR1 (0.97) GPBAR1SLC10A2SLC10A1TSHRRAB9A
Taurocholic Acid SCHEMBL3706 0.99 GPBAR1 (1.00) GPBAR1SLC10A2SLC10A1TSHRRAB9A
Taurocholic Acid SCHEMBL22852508 0.99 GPBAR1 (1.00) GPBAR1SLC10A2SLC10A1TSHRRAB9A
Taurocholic Acid SCHEMBL24486612 0.99 GPBAR1 (1.00) GPBAR1SLC10A2SLC10A1TSHRRAB9A
Taurocholic Acid SCHEMBL10696857 0.99 GPBAR1 (1.00) GPBAR1SLC10A2SLC10A1TSHRRAB9A
Taurocholic Acid SCHEMBL20493965 0.99 GPBAR1 (1.00) GPBAR1SLC10A2SLC10A1TSHRRAB9A
Taurocholic Acid SCHEMBL24001492 0.99 GPBAR1 (1.00) GPBAR1SLC10A2SLC10A1TSHRRAB9A
Taurocholic Acid SCHEMBL435030 0.99 GPBAR1 (1.00) GPBAR1SLC10A2SLC10A1TSHRRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1196 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240058454-A1 BIOLOGICAL DELIVERY SYSTEMS PARTICELLA INC (US) 2024-02-22 US claimed
EP-4259099-A1 BIOLOGICAL DELIVERY SYSTEMS Particella, Inc. (US) 2023-10-18 EP claimed
WO-2022132678-A1 BIOLOGICAL DELIVERY SYSTEMS DNALITE THERAPEUTICS, INC. (US) 2022-06-23 WO claimed
CN-114469826-A Gel type Zhejiang radix ophiopogonis whitening mask and preparation method thereof 浙江省林业科学研究院 2022-05-13 CN claimed
CN-114195852-A Preparation method of 3 beta, 7 beta-dihydroxy-5 beta-cholanic acid 中山百灵生物技术股份有限公司 2022-03-18 CN claimed
WO-2021070883-A1 HUMAN NTCP-BINDING ANTIBODY CAPABLE OF INHIBITING INFECTION OF HEPATITIS B VIRUS (HBV) TO HUMAN HEPATOCYTES 国立研究開発法人理化学研究所 2021-04-15 WO claimed
CN-112505187-A Method for detecting bile acid in excrement by UPLC-MS/MS (ultra Performance liquid chromatography-Mass Spectrometry/Mass Spectrometry) combination 北京诺禾致源科技股份有限公司 2021-03-16 CN claimed
US-20210071097-A1 Droplet for Fuels KAMTERTER PRODUCTS, LLC (US) 2021-03-11 US claimed
WO-2020182228-A1 METHOD OF REFINING SODIUM TAUROCHOLATE 美药星(南京)制药有限公司 2020-09-17 WO claimed
EP-3443335-A1 SYSTEMS AND METHODS FOR ELECTROCHEMICAL TRIGLYCERIDES ASSAYS Polymer Technology Systems, Inc. (US) 2019-02-20 EP claimed
US-20080063708-A1 Pharmaceutical Compositions of Amorphous Dispersions of Drugs and Lipophilic Microphase-Forming Materials LONZA BEND INC. 2008-03-13 US claimed
CN-100349915-C Amido glycoside of sea pearl oyster, prepartion method, and usage NANHAI INST OF OCEAN C A S (CN) 2007-11-21 CN claimed
CN-1916021-A Amido glycoside of sea pearl oyster, prepartion method, and usage NANHAI INST OF OCEAN C A S (CN) 2007-02-21 CN claimed
CN-1810947-A Garlic oil refining process and the prepn process of its emulsion and solid nanometer liposome particle GUO TAO (CN) 2006-08-02 CN claimed
EP-1653927-A2 PHARMACEUTICAL COMPOSITIONS OF ADSORBATES OF AMORPHOUS DRUGS AND LIPOPHILIC MICROPHASE-FORMING MATERIALS Pfizer Products Inc. (US) 2006-05-10 EP claimed
CN-1593649-A Method for preparing insulin oral formulation YU XIAOLING (CN) 2005-03-16 CN claimed
US-20050031693-A1 Combination of a solid adsorbate and a lipophilic microphase-forming material results in improved dissolved concentration of the drug in the aqueous use environment PFIZER INC 2005-02-10 US claimed
WO-2005011635-A2 PHARMACEUTICAL COMPOSITIONS OF ADSORBATES OF AMORPHOUS DRUGS AND LIPOPHILIC MICROPHASE-FORMING MATERIALS PFIZER PRODUCTS INC. (US) 2005-02-10 WO claimed
CN-1259142-A Zinc-free insulin crystal composition for lung NOVO NORDISK AS (DK) 2000-07-05 CN claimed
CN-1171049-A Powder formulations containing melezitose as diluent ASTRA AB (SE) 1998-01-21 CN claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080063708-A1 Pharmaceutical Compositions of Amorphous Dispersions of Drugs and Lipophilic Microphase-Forming Materials ABCG2, LIPA, ABCB1 GPBAR1 1234/4885SLC10A2 444/4885SLC10A1 129/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.