SCHEMBL12424230

SCHEMBL12424230

C=CC(=O)Oc1c(C(C)c2cc(C(C)(C)CC)cc(C(C)C(C)C)c2O)cc(C(C)(C)CC)cc1C(C)(C)CC

nearest known ligand 0.35

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ RXRA P19793 5/20 0.35
▸ PPARG P37231 5/20 0.35
▸ RARG P13631 4/20 0.35
▸ RARA P10276 1/20 0.33
▸ RARB P10826 1/20 0.33
▸ RXRB P28702 1/20 0.33
▸ RXRG P48443 1/20 0.33
▸ MEN1 O00255 1/20 0.30
▸ ALDH1A1 P00352 1/20 0.30
▸ MAPK1 P28482 1/20 0.30
▸ KMT2A Q03164 1/20 0.30
▸ SMN1; SMN2 Q16637 1/20 0.30
▸ NPSR1 Q6W5P4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12424227 0.93 — —
SCHEMBL12424228 0.92 RXRA (0.33) RXRAPPARGRARGRARARARB
SCHEMBL13356449 0.92 RXRA (0.36) RXRAPPARGRARGRARARARB
SCHEMBL29353638 0.92 RXRA (0.37) RXRAPPARGRARGRARARARB
SCHEMBL237192 0.92 RXRA (0.37) RXRAPPARGRARGRARARARB
SCHEMBL29464292 0.92 RXRA (0.37) RXRAPPARGRARGRARARARB
SCHEMBL13356450 0.90 RXRA (0.35) RXRAPPARGRARGRARARARB
SCHEMBL13356407 0.90 RXRA (0.36) RXRAPPARGRARGRARARARB
SCHEMBL14125277 0.90 RXRA (0.36) RXRAPPARGRARGRARARARB
SCHEMBL4411077 0.88 CYP1A2 (0.39) RXRAPPARGRARGRARARARB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7977418-B2 Bisphenol monoester-based stabilizer composition, thermoplastic polymer composition and method of manufacturing the same, thermoplastic polymer molded product, and method of stabilizing thermoplastic polymer SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-07-12 — — US disclosed
US-7977418-B2 Bisphenol monoester-based stabilizer composition, thermoplastic polymer composition and method of manufacturing the same, thermoplastic polymer molded product, and method of stabilizing thermoplastic polymer SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2011-07-12 — — US disclosed
EP-2022819-B1 Bisphenol monoester-based stabilizer composition, thermoplastic polymer composition and method of manufacturing the same, thermoplastic polymer molded product, and method of stabilizing thermoplastic polymer SUMITOMO CHEMICAL CO (JP) 2010-05-12 — — EP disclosed
US-20090043027-A1 Bisphenol monoester-based stabilizer composition, thermoplastic polymer composition and method of manufacturing the same, thermoplastic polymer molded product, and method of stabilizing thermoplastic polymer SUMITOMO CHEMICAL COMPANY, LIMITED 2009-02-12 — — US disclosed
US-20090043027-A1 Bisphenol monoester-based stabilizer composition, thermoplastic polymer composition and method of manufacturing the same, thermoplastic polymer molded product, and method of stabilizing thermoplastic polymer SUMITOMO CHEMICAL COMPANY, LIMITED 2009-02-12 — — US disclosed
EP-2022819-A1 Bisphenol monoester-based stabilizer composition, thermoplastic polymer composition and method of manufacturing the same, thermoplastic polymer molded product, and method of stabilizing thermoplastic polymer Sumitomo Chemical Company, Limited (JP) 2009-02-11 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090043027-A1 Bisphenol monoester-based stabilizer composition, thermoplastic polymer composition and method of manufacturing the same, thermoplastic polymer molded product, and method of stabilizing thermoplastic polymer PCBP1, MMS19, PUF60 RXRA 647/4885PPARG 350/4885RARG 601/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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