Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CTSD | P07339 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15014609 | 0.83 | ALDH1A1 (0.56) | ALDH1A1KDM4ELMNAL3MBTL1CYP3A4 | |
| SCHEMBL13308126 | 0.82 | ALDH1A1 (0.43) | ALDH1A1KDM4ELMNAL3MBTL1CYP3A4 | |
| SCHEMBL18082558 | 0.80 | ALDH1A1 (0.41) | ALDH1A1LMNANAMPTKMT2AMEN1 | |
| SCHEMBL12384811 | 0.80 | ALDH1A1 (0.46) | ALDH1A1KDM4ELMNAL3MBTL1CYP3A4 | |
| SCHEMBL21581035 | 0.79 | POLB (0.45) | ALDH1A1LMNAHPGDKMT2AMEN1 | |
| SCHEMBL26286141 | 0.78 | KDM4E (0.41) | ALDH1A1KDM4ELMNAL3MBTL1CYP3A4 | |
| SCHEMBL26286625 | 0.78 | KDM4E (0.41) | ALDH1A1KDM4ELMNAL3MBTL1CYP3A4 | |
| SCHEMBL13686205 | 0.77 | MEN1 (0.46) | ALDH1A1KDM4ELMNAHPGDKMT2A | |
| SCHEMBL22875137 | 0.74 | KDM4E (0.46) | ALDH1A1KDM4ELMNAL3MBTL1CYP3A4 | |
| SCHEMBL24182540 | 0.74 | ALDH1A1 (0.65) | ALDH1A1LMNAHPGDKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461328-B2 | Tricyclic heterocyclic compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20110201593-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201593-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | CCNY, CCNA1, CCNA2 | ALDH1A1 1168/4885KDM4E 2333/4885LMNA 1043/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.