Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.59 |
| ▸ | FLT3 | P36888 | 7/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.56 |
| ▸ | NTRK2 | Q16620 | 3/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.56 |
| ▸ | RET | P07949 | 2/20 | 0.56 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.56 |
| ▸ | LTK | P29376 | 1/20 | 0.56 |
| ▸ | CDK8 | P49336 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.56 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 6/20 | 0.51 |
| ▸ | CSF1R | P07333 | 5/20 | 0.51 |
| ▸ | FLT1 | P17948 | 5/20 | 0.51 |
| ▸ | LCK | P06239 | 4/20 | 0.51 |
| ▸ | FLT4 | P35916 | 4/20 | 0.51 |
| ▸ | ABL1 | P00519 | 3/20 | 0.51 |
| ▸ | FYN | P06241 | 3/20 | 0.51 |
| ▸ | LYN | P07948 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2235566 | 0.89 | KDR (0.59) | KDRFLT3PDGFRBNTRK1NTRK2 | |
| SCHEMBL1703031 | 0.79 | KDR (0.60) | KDRFLT3PDGFRBNTRK1NTRK2 | |
| SCHEMBL13209956 | 0.78 | KDR (0.80) | KDRFLT3PDGFRBNTRK1NTRK2 | |
| SCHEMBL2238775 | 0.78 | RAF1 (0.55) | KDRFLT3PDGFRBKITCSF1R | |
| SCHEMBL3842668 | 0.77 | KDR (0.59) | KDRFLT3PDGFRBNTRK1NTRK2 | |
| SCHEMBL14270630 | 0.77 | KDR (0.55) | KDRFLT3PDGFRBNTRK1NTRK2 | |
| SCHEMBL13873229 | 0.76 | KDR (0.70) | KDRFLT3PDGFRBNTRK1NTRK2 | |
| SCHEMBL13541769 | 0.76 | CA12 (0.69) | KDRFLT3PDGFRBNTRK1NTRK2 | |
| SCHEMBL1702846 | 0.76 | RIPK1 (0.54) | KDRFLT3PDGFRBNTRK1NTRK2 | |
| SCHEMBL2904038 | 0.75 | KDR (0.55) | KDRFLT3PDGFRBNTRK1NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008322-B2 | Substituted pyrazolopyridines, compositions containing them, method for the production thereof, and their use | AVENTIS PHARMA S.A. (FR) | 2011-08-30 | — | — | US | disclosed |
| US-20080039491-A1 | SUBSTITUTED PYRAZOLOPYRIDINES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE | AVENTIS PHARMA S.A. (FR) | 2008-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039491-A1 | SUBSTITUTED PYRAZOLOPYRIDINES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF, AND THEIR USE | DPYD, TYMP, PCK2 | KDR 2947/4885FLT3 121/4885PDGFRB 1523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.