SCHEMBL12424708

SCHEMBL12424708

COc1ccc(C2(c3ccc(N4CCOCC4)cc3)C=Cc3c4c(c5cc(OC)c(OC)cc5c3O2)-c2ccccc2-c2ccccc2C42CC(C)(C)C2)cc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
STK10 O94804 1/20 0.34
SLK Q9H2G2 1/20 0.34
MEN1 O00255 3/20 0.32
KMT2A Q03164 3/20 0.32
MAPT P10636 4/20 0.32
KDM4E B2RXH2 2/20 0.32
ALDH1A1 P00352 2/20 0.32
RAB9A P51151 2/20 0.32
HTT P42858 1/20 0.32
SLC6A3 Q01959 1/20 0.32
NPC1 O15118 1/20 0.32
LMNA P02545 1/20 0.32
HPGD P15428 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
PRKDC P78527 2/20 0.31
RXFP1 Q9HBX9 1/20 0.31
PIK3CA P42336 1/20 0.31
PDK2 Q15119 1/20 0.31
AKT1 P31749 1/20 0.31
ADAM17 P78536 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13868628 0.92 PRKDC (0.34) STK10SLKMEN1KMT2AMAPT
SCHEMBL10292860 0.92 PRKDC (0.34) STK10SLKMEN1KMT2AMAPT
SCHEMBL13868685 0.92 PRKDC (0.34) STK10SLKMEN1KMT2AMAPT
SCHEMBL13868686 0.92 PRKDC (0.34) STK10SLKMEN1KMT2AMAPT
SCHEMBL13868669 0.92 TTK (0.33) STK10SLKMEN1KMT2AMAPT
SCHEMBL10021753 0.92 KDM4E (0.33) STK10SLKMAPTKDM4EALDH1A1
SCHEMBL12424707 0.91 MAPT (0.33) STK10SLKMEN1KMT2AMAPT
SCHEMBL12189458 0.91 PRKDC (0.33) STK10SLKMEN1KMT2AMAPT
SCHEMBL13868745 0.91 ALDH1A1 (0.35) MEN1KMT2AMAPTKDM4EALDH1A1
SCHEMBL13868646 0.91 PRKDC (0.36) STK10SLKMEN1KMT2AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7976739-B2 Chromene compound TOKUYAMA CORPORATION (JP) 2011-07-12 US disclosed
US-7976739-B2 Chromene compound TOKUYAMA CORPORATION (JP) 2011-07-12 US disclosed
US-20100230649-A1 CHROMENE COMPOUND TOKUYAMA CORPORATION (JP) 2010-09-16 US disclosed
US-20100230649-A1 CHROMENE COMPOUND TOKUYAMA CORPORATION (JP) 2010-09-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100230649-A1 CHROMENE COMPOUND CCNT1, RB1, H1-0 STK10 1846/4885SLK 1979/4885MEN1 576/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.