SCHEMBL10021753

SCHEMBL10021753

COc1ccc(C2(c3ccc(N4CCOCC4)cc3)C=Cc3c4c(c5cc(-c6ccc(OC)cc6OC)c(OC)cc5c3O2)-c2ccccc2C42CC(C)(C)CC(C)(C)C2)cc1

nearest known ligand 0.33

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
MAPT P10636 1/20 0.33
HTT P42858 1/20 0.33
STK10 O94804 1/20 0.32
SLK Q9H2G2 1/20 0.32
ATR Q13535 1/20 0.31
ATRIP Q8WXE1 1/20 0.31
ADAM17 P78536 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10262628 0.98 KDM4E (0.32) KDM4EALDH1A1MAPTHTTSTK10
SCHEMBL12205490 0.98 KDM4E (0.32) KDM4EALDH1A1MAPTHTTSTK10
SCHEMBL13868716 0.95 KDM4E (0.31) KDM4EALDH1A1MAPTHTTSTK10
SCHEMBL13868712 0.95 KDM4E (0.34) KDM4EALDH1A1MAPTHTTATR
SCHEMBL13868628 0.94 PRKDC (0.34) KDM4EALDH1A1MAPTHTTSTK10
SCHEMBL13868685 0.94 PRKDC (0.34) KDM4EALDH1A1MAPTHTTSTK10
SCHEMBL10292860 0.94 PRKDC (0.34) KDM4EALDH1A1MAPTHTTSTK10
SCHEMBL13868686 0.93 PRKDC (0.34) KDM4EALDH1A1MAPTSTK10SLK
SCHEMBL10261675 0.93 ATR (0.31) ATRATRIP
SCHEMBL13868669 0.93 TTK (0.33) KDM4EALDH1A1MAPTHTTSTK10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240241291-A1 FUNCTIONAL LAMINATE AND FUNCTIONAL LENS COMPRISING THE FUNCTIONAL LAMINATE TOKUYAMA CORPORATION (JP) 2024-07-18 US disclosed
US-20230272252-A1 ADHESIVE COMPOSITION, LAMINATE AND OPTICAL ARTICLE COMPRISING THE LAMINATE TOKUYAMA CORPORATION (JP) 2023-08-31 US disclosed
EP-3345954-B1 POLYROTAXANE, PRODUCTION METHOD THEREFOR, AND OPTICAL COMPOSITION CONTAINING SAID POLYROTAXANE TOKUYAMA CORP (JP) 2023-07-05 EP disclosed
US-11649327-B2 Photochromic curable composition, use thereof, and polyrotaxane monomers TOKUYAMA CORPORATION (JP) 2023-05-16 US disclosed
US-11578174-B2 Polyrotaxane, production method therefor, and optical composition containing said polyrotaxane TOKUYAMA CORPORATION (JP) 2023-02-14 US disclosed
US-20220162486-A1 PHOTOCHROMIC OPTICAL ARTICLE AND METHOD FOR MANUFACTURING SAME TOKUYAMA CORPORATION (JP) 2022-05-26 US disclosed
EP-3950624-A1 PHOTOCHROMIC OPTICAL ARTICLE AND METHOD FOR MANUFACTURING SAME Tokuyama Corporation (JP) 2022-02-09 EP disclosed
EP-3330751-B1 METHOD OF PRODUCING A PHOTOCHROMIC LAMINATE TOKUYAMA CORP (JP) 2021-05-26 EP disclosed
EP-3399368-B1 LAMINATE AND OPTICAL ARTICLE USING SAID LAMINATE TOKUYAMA CORP (JP) 2021-02-24 EP disclosed
US-20210002545-A1 PHOTOCHROMIC CURABLE COMPOSITION TOKUYAMA CORPORATION (JP) 2021-01-07 US disclosed
WO-2012018070-A1 PHOTOCHROMIC COMPOSITION 株式会社トクヤマ (JP) 2012-02-09 WO disclosed
US-20110062396-A1 CHROMENE COMPOUND TOKUYAMA CORPORATION (JP) 2011-03-17 US disclosed
EP-2275418-A1 CHROMENE COMPOUND Tokuyama Corporation (JP) 2011-01-19 EP disclosed
US-7521004-B2 Chromene compound TOKUYAMA CORPORATION (JP) 2009-04-21 US disclosed
US-7521004-B2 Chromene compound TOKUYAMA CORPORATION (JP) 2009-04-21 US disclosed
EP-1674460-B1 CHROMENE COMPOUND TOKUYAMA CORP (JP) 2009-01-21 EP disclosed
US-20080058444-A1 Polymerization Curable Composition TOKUYAMA CORPORATION (JP) 2008-03-06 US disclosed
US-20070215844-A1 Chromene Compound TOKUYAMA CORPORATION (JP) 2007-09-20 US disclosed
US-20070215844-A1 Chromene Compound TOKUYAMA CORPORATION (JP) 2007-09-20 US disclosed
EP-1810982-A1 POLYMERIZATION-CURABLE COMPOSITION Tokuyama Corporation (JP) 2007-07-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070215844-A1 Chromene Compound CRY2, TYR, CRY1 KDM4E 1354/4885ALDH1A1 2110/4885MAPT 520/4885
US-20110062396-A1 CHROMENE COMPOUND CDYL, NR0B1, NR1H2 KDM4E 2629/4885ALDH1A1 1987/4885MAPT 4740/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.