Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | AR | P10275 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16520919 | 0.90 | HTT (0.50) | HTTSMN1; SMN2TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL26572702 | 0.87 | PKM (0.50) | HTTSMN1; SMN2TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL12425090 | 0.85 | PKM (0.51) | HTTSMN1; SMN2TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL15760415 | 0.85 | MAPT (0.53) | HTTSMN1; SMN2TDP1L3MBTL1HSD11B1 | |
| SCHEMBL16520920 | 0.82 | HSD11B1 (0.46) | HTTSMN1; SMN2TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL9914249 | 0.81 | HTT (0.58) | HTTSMN1; SMN2TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL12426029 | 0.79 | MAPT (0.48) | HTTSMN1; SMN2TDP1L3MBTL1HSD11B1 | |
| SCHEMBL12425105 | 0.79 | MAPT (0.42) | HTTSMN1; SMN2TDP1L3MBTL1HSD11B1 | |
| SCHEMBL14264189 | 0.78 | MAPT (0.69) | HTTSMN1; SMN2TDP1L3MBTL1ALDH1A1 | |
| SCHEMBL822653 | 0.77 | HTT (0.65) | HTTSMN1; SMN2TDP1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977451-B2 | polyphenylene ethers used for blood dialysis and filtration | GENERAL ELECTRIC COMPANY (US) | 2011-07-12 | — | — | US | disclosed |
| US-7695628-B2 | hollow fiber modules comprising blends of polyphenylene ethers block polymers and polyvinylpyrrolidone, used for blood dialysis and filtration | GENERAL ELECTRIC COMPANY (US) | 2010-04-13 | — | — | US | disclosed |
| US-20080142443-A1 | POLYARYLETHER MEMBRANES | GENERAL ELECTRIC (US) | 2008-06-19 | — | — | US | disclosed |
| US-20080142442-A1 | hollow fiber modules comprising blends of polyphenylene ethers block polymers and polyvinylpyrrolidone, used for blood dialysis and filtration | GENERAL ELECTRIC (US) | 2008-06-19 | — | — | US | disclosed |