Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 5/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 4/20 | 1.00 |
| ▸ | HDAC3 | O15379 | 3/20 | 1.00 |
| ▸ | HDAC2 | Q92769 | 3/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 1.00 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.90 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.90 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.90 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.90 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.90 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.90 |
| ▸ | GSK3B | P49841 | 1/20 | 0.71 |
| ▸ | F3 | P13726 | 2/20 | 0.70 |
| ▸ | THRB | P10828 | 2/20 | 0.68 |
| ▸ | ATM | Q13315 | 1/20 | 0.68 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.67 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14244673 | 1.00 | HDAC8 (1.00) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL3292536 | 0.95 | HDAC8 (1.00) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL3292542 | 0.95 | HDAC8 (1.00) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL1321123 | 0.91 | HDAC3 (0.82) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL1321125 | 0.91 | HDAC3 (0.82) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL11707965 | 0.89 | HDAC3 (0.80) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL11707977 | 0.89 | HDAC3 (0.80) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL13253697 | 0.87 | HDAC3 (0.77) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL459670 | 0.86 | HDAC3 (0.75) | HDAC8HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL459669 | 0.86 | HDAC3 (0.75) | HDAC8HDAC1HDAC3HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210030899-A1 | IMAGING HISTONE DEACETYLASES WITH A RADIOTRACER USING POSITRON EMISSION TOMOGRAPHY | THE GENERAL HOSPITAL CORPORATION | 2021-02-04 | — | — | US | disclosed |
| US-10842891-B2 | Imaging histone deacetylases with a radiotracer using positron emission tomography | THE GENERAL HOSPITAL CORPORATION (US) | 2020-11-24 | — | — | US | disclosed |
| US-20190240357-A1 | IMAGING HISTONE DEACETYLASES WITH A RADIOTRACER USING POSITRON EMISSION TOMOGRAPHY | THE GENERAL HOSPITAL CORPORATION | 2019-08-08 | — | — | US | disclosed |
| US-10188756-B2 | Imaging histone deacetylases with a radiotracer using positron emission tomography | THE GENERAL HOSPITAL CORPORATION (US) | 2019-01-29 | — | — | US | disclosed |
| US-20160271276-A1 | IMAGING HISTONE DEACETYLASES WITH A RADIOTRACER USING POSITRON EMISSION TOMOGRAPHY | THE GENERAL HOSPITAL CORPORATION | 2016-09-22 | — | — | US | disclosed |
| US-20160271276-A1 | IMAGING HISTONE DEACETYLASES WITH A RADIOTRACER USING POSITRON EMISSION TOMOGRAPHY | THE GENERAL HOSPITAL CORPORATION | 2016-09-22 | — | — | US | disclosed |
| US-9260382-B2 | Methods of reducing virulence in bacteria | UWM RESEARCH FOUNDATION (US) | 2016-02-16 | — | — | US | disclosed |
| US-9260382-B2 | Methods of reducing virulence in bacteria | UWM RESEARCH FOUNDATION (US) | 2016-02-16 | — | — | US | disclosed |
| US-9260382-B2 | Methods of reducing virulence in bacteria | UWM RESEARCH FOUNDATION (US) | 2016-02-16 | — | — | US | disclosed |
| US-20120322769-A1 | METHODS OF REDUCING VIRULENCE IN BACTERIA | DUKE UNIVERSITY (US) | 2012-12-20 | — | — | US | disclosed |
| US-20120322769-A1 | METHODS OF REDUCING VIRULENCE IN BACTERIA | DUKE UNIVERSITY (US) | 2012-12-20 | — | — | US | disclosed |
| US-20120322769-A1 | METHODS OF REDUCING VIRULENCE IN BACTERIA | DUKE UNIVERSITY (US) | 2012-12-20 | — | — | US | disclosed |
| WO-2011103189-A1 | METHODS OF REDUCING VIRULENCE IN BACTERIA | UWM RESEARCH FOUNDATION, INC. (US) | 2011-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190240357-A1 | IMAGING HISTONE DEACETYLASES WITH A RADIOTRACER USING POSITRON EMISSION TOMOGRAPHY | HDAC1, HDAC11, HDAC3 | HDAC8 7/4885HDAC1 1/4885HDAC3 3/4885 |
| US-10188756-B2 | Imaging histone deacetylases with a radiotracer using positron emission tomography | HDAC1, HDAC11, HDAC3 | HDAC8 7/4885HDAC1 1/4885HDAC3 3/4885 |
| US-20210030899-A1 | IMAGING HISTONE DEACETYLASES WITH A RADIOTRACER USING POSITRON EMISSION TOMOGRAPHY | HDAC1, HDAC11, HDAC3 | HDAC8 7/4885HDAC1 1/4885HDAC3 3/4885 |
| US-20160271276-A1 | IMAGING HISTONE DEACETYLASES WITH A RADIOTRACER USING POSITRON EMISSION TOMOGRAPHY | HDAC1, HDAC11, HDAC3 | HDAC8 7/4885HDAC1 1/4885HDAC3 3/4885 |
| US-20120322769-A1 | METHODS OF REDUCING VIRULENCE IN BACTERIA | PGLS, RRS1, MRPL21 | HDAC8 3068/4885HDAC1 3651/4885HDAC3 2208/4885 |
| US-10842891-B2 | Imaging histone deacetylases with a radiotracer using positron emission tomography | HDAC1, HDAC11, HDAC3 | HDAC8 7/4885HDAC1 1/4885HDAC3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.