Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 16/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | ACVR1B | P36896 | 8/20 | 0.51 |
| ▸ | ACVRL1 | P37023 | 7/20 | 0.51 |
| ▸ | WNT1 | P04628 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12424767 | 0.93 | TGFBR1 (0.64) | TGFBR1CYP3A4ACVR1BACVRL1BMPR1A | |
| SCHEMBL12094126 | 0.82 | TGFBR1 (0.55) | TGFBR1CYP3A4ACVR1BACVRL1WNT1 | |
| SCHEMBL12090419 | 0.82 | TGFBR1 (0.65) | TGFBR1CYP3A4ACVR1BACVRL1BMPR1A | |
| SCHEMBL12424830 | 0.78 | ABL1 (0.46) | WNT1DYRK1ACDK2 | |
| SCHEMBL2298018 | 0.77 | NUDT1 (0.60) | TGFBR1CYP3A4ACVR1BACVRL1BMPR1A | |
| SCHEMBL12424843 | 0.77 | TGFBR1 (0.54) | TGFBR1CYP3A4ACVR1BACVRL1BMPR1A | |
| SCHEMBL12424789 | 0.75 | TGFBR1 (0.59) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL12426550 | 0.75 | TGFBR1 (0.40) | TGFBR1CYP3A4ACVR1BACVRL1ACVR1 | |
| SCHEMBL12424824 | 0.74 | TGFBR1 (0.58) | TGFBR1CYP3A4ACVR1BACVRL1BMPR1A | |
| SCHEMBL12424790 | 0.74 | TGFBR1 (0.64) | TGFBR1CYP3A4ACVR1BACVRL1BMPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539336-B1 | HETARYLAMINONAPHTHYRIDINES | MERCK PATENT GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |
| US-8815893-B2 | Hetarylaminonaphthyridines | MERCK PATENT GMBH (DE) | 2014-08-26 | — | — | US | disclosed |
| US-8815893-B2 | Hetarylaminonaphthyridines | MERCK PATENT GMBH (DE) | 2014-08-26 | — | — | US | disclosed |
| US-20120316166-A1 | HETARYLAMINONAPHTHYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-12-13 | — | — | US | disclosed |
| US-20120316166-A1 | HETARYLAMINONAPHTHYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2012-12-13 | — | — | US | disclosed |
| WO-2011101069-A2 | HETARYLAMINONAPHTHYRIDINES | MERCK PATENT GMBH (DE) | 2011-08-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120316166-A1 | HETARYLAMINONAPHTHYRIDINES | ATP5ME, ATP5F1A, ATP5F1D | TGFBR1 3742/4885CYP3A4 828/4885ACVR1B 4144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.