Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.34 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12427668 | 0.92 | PRKCA (0.45) | PRKCAMMP12NR1I2SCN9A | |
| SCHEMBL12427641 | 0.91 | PRKCA (0.46) | PRKCAMMP12NPC1L1NR1I2SCN9A | |
| SCHEMBL12427653 | 0.91 | PRKCA (0.45) | PRKCAMMP12NR1I2SCN9AKDM4E | |
| SCHEMBL10283270 | 0.90 | PRKCA (0.44) | PRKCAMMP12CHRM3NR1I2SCN9A | |
| SCHEMBL12427933 | 0.90 | PRKCA (0.44) | PRKCAMMP12NR1I2SCN9A | |
| SCHEMBL803750 | 0.89 | PRKCA (0.47) | PRKCAMMP12NR1I2SCN9A | |
| SCHEMBL12427597 | 0.88 | PRKCA (0.49) | PRKCAMMP12NR1I2SCN9AKDM4E | |
| SCHEMBL12427917 | 0.88 | PRKCA (0.46) | PRKCAMMP12CHRM2CHRM4CHRM1 | |
| SCHEMBL12427642 | 0.88 | PRKCA (0.45) | PRKCAMMP12NPC1L1NR1I2SCN9A | |
| SCHEMBL804194 | 0.88 | PRKCA (0.48) | PRKCAMMP12NR1I2SCN9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |