Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.39 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.36 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12428390 | 0.93 | PRKCA (0.43) | PRKCAMMP12SCN9ACYP2C9 | |
| SCHEMBL12429429 | 0.93 | KDM4E (0.39) | PRKCAMMP12KDM4EPKMGPR119 | |
| SCHEMBL12427652 | 0.91 | PRKCA (0.44) | PRKCAMMP12KDM4EPKMGPR119 | |
| SCHEMBL792654 | 0.91 | GPR119 (0.40) | KDM4EPKMGPR119TGFBR1 | |
| SCHEMBL803973 | 0.90 | PRKCA (0.48) | PRKCAMMP12KDM4ESCN9ANR1I2 | |
| SCHEMBL12427743 | 0.88 | PRKCA (0.43) | PRKCAMMP12SCN9ANR1I2CYP3A4 | |
| SCHEMBL10283182 | 0.87 | GPR119 (0.37) | KDM4EPKMGPR119TGFBR1 | |
| SCHEMBL12427646 | 0.87 | PRKCA (0.46) | PRKCAMMP12SCN9ANR1I2CYP3A4 | |
| SCHEMBL12427731 | 0.87 | PRKCA (0.44) | PRKCAMMP12SCN9A | |
| SCHEMBL12427690 | 0.86 | PRKCA (0.46) | PRKCAMMP12SCN9ANR1I2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |