Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPY1R | P25929 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12428227 | 0.94 | PRKCA (0.41) | PRKCAMMP12KDM2BLTA4HEPHX2 | |
| SCHEMBL12428179 | 0.93 | PRKCA (0.41) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL12428247 | 0.92 | PRKCA (0.43) | PRKCAMMP12KDM2BNR1I2CYP3A4 | |
| SCHEMBL13286276 | 0.91 | PRKCA (0.41) | PRKCAMMP12KDM2BNR1I2CYP3A4 | |
| SCHEMBL10283489 | 0.91 | EGFR (0.44) | PRKCAMMP12EGFRKDM4EALDH1A1 | |
| SCHEMBL12428353 | 0.90 | PRKCA (0.39) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL10283245 | 0.88 | PRKCA (0.47) | PRKCAMMP12KDM2BNR1I2CYP3A4 | |
| SCHEMBL12428189 | 0.88 | PRKCA (0.42) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL12428298 | 0.87 | PRKCA (0.40) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL12429156 | 0.87 | PRKCA (0.40) | PRKCAMMP12NR1I2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |