Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13286276 | 0.92 | PRKCA (0.41) | PRKCAMMP12HRH3KDM2BALDH1A1 | |
| SCHEMBL10283489 | 0.92 | EGFR (0.44) | PRKCAMMP12HRH3ALDH1A1NPC1 | |
| SCHEMBL12428182 | 0.92 | PRKCA (0.42) | PRKCAMMP12HRH3KDM2BALDH1A1 | |
| SCHEMBL804220 | 0.92 | PRKCA (0.41) | PRKCAMMP12HRH3ALDH1A1MEN1 | |
| SCHEMBL12428227 | 0.91 | PRKCA (0.41) | PRKCAMMP12KDM2BALDH1A1NPC1 | |
| SCHEMBL804200 | 0.90 | PRKCA (0.40) | PRKCAMMP12HRH3ALDH1A1MAPT | |
| SCHEMBL12427725 | 0.88 | PRKCA (0.48) | PRKCAMMP12HRH3ALDH1A1MAPT | |
| SCHEMBL12427922 | 0.87 | PRKCA (0.51) | PRKCAMMP12KDM2BNR1I2CYP3A4 | |
| SCHEMBL12428156 | 0.86 | PRKCA (0.43) | PRKCAMMP12HRH3ALDH1A1MAPT | |
| SCHEMBL803751 | 0.86 | PRKCA (0.44) | PRKCAMMP12HRH3ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |