Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 6/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | CCR3 | P51677 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12428207 | 0.94 | PRKCA (0.40) | PRKCAMMP12SCN9AKCNH2NR1I2 | |
| SCHEMBL12428402 | 0.91 | PRKCA (0.42) | PRKCAMMP12SCN9AKCNH2NR1I2 | |
| SCHEMBL12427984 | 0.91 | PRKCA (0.42) | PRKCAMMP12SCN9AKCNH2NR1I2 | |
| SCHEMBL12427924 | 0.91 | PRKCA (0.42) | PRKCAMMP12SCN9AKCNH2NR1I2 | |
| SCHEMBL10283247 | 0.90 | PRKCA (0.47) | PRKCAMMP12SCN9AKCNH2NR1I2 | |
| SCHEMBL12428184 | 0.89 | PRKCA (0.40) | PRKCAMMP12SCN9AKCNH2NR1I2 | |
| SCHEMBL12428426 | 0.87 | PRKCA (0.40) | PRKCAMMP12SCN9AKCNH2NR1I2 | |
| SCHEMBL12428253 | 0.87 | PRKCA (0.41) | PRKCAMMP12KCNH2NR1I2CYP3A4 | |
| SCHEMBL12428477 | 0.86 | PRKCA (0.41) | PRKCAMMP12SCN9AKCNH2NR1I2 | |
| SCHEMBL10283198 | 0.86 | PRKCA (0.41) | PRKCAMMP12SCN9AKCNH2NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |