Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | VDR | P11473 | 2/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12428184 | 0.92 | PRKCA (0.40) | PRKCAMMP12NR1I2CYP3A4KCNH2 | |
| SCHEMBL12428426 | 0.91 | PRKCA (0.40) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL10283247 | 0.88 | PRKCA (0.47) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL12428293 | 0.87 | PRKCA (0.41) | PRKCAMMP12NR1I2CYP3A4KCNH2 | |
| SCHEMBL12427984 | 0.87 | PRKCA (0.42) | PRKCAMMP12NR1I2KCNH2 | |
| SCHEMBL12428402 | 0.87 | PRKCA (0.42) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL12427924 | 0.86 | PRKCA (0.42) | PRKCAMMP12NR1I2CYP3A4CYP2C19 | |
| SCHEMBL12428182 | 0.86 | PRKCA (0.42) | PRKCAMMP12NR1I2CYP3A4CYP2C9 | |
| SCHEMBL12428207 | 0.86 | PRKCA (0.40) | PRKCAMMP12NR1I2KCNH2 | |
| SCHEMBL12428227 | 0.85 | PRKCA (0.41) | PRKCAMMP12NR1I2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |