Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12427956 | 0.99 | PRKCA (0.42) | PRKCAMMP12KDM2BMCL1SCN9A | |
| SCHEMBL12428150 | 0.99 | PRKCA (0.42) | PRKCAMMP12KDM2BMCL1SCN9A | |
| SCHEMBL12428144 | 0.99 | PRKCA (0.42) | PRKCAMMP12KDM2BMCL1SCN9A | |
| SCHEMBL12428410 | 0.95 | PRKCA (0.43) | PRKCAMMP12KDM2BMCL1SCN9A | |
| SCHEMBL12428329 | 0.95 | PRKCA (0.41) | PRKCAMMP12KDM2BMCL1SCN9A | |
| SCHEMBL12427977 | 0.93 | PRKCA (0.41) | PRKCAMMP12KDM2BMCL1SCN9A | |
| SCHEMBL12428449 | 0.93 | PRKCA (0.40) | PRKCAMMP12KDM2BMCL1SCN9A | |
| SCHEMBL12428040 | 0.92 | PRKCA (0.41) | PRKCAMMP12KDM2BMCL1SCN9A | |
| SCHEMBL12428452 | 0.91 | PRKCA (0.40) | PRKCAMMP12KDM2BSCN9AKCNH2 | |
| SCHEMBL10283578 | 0.91 | PRKCA (0.43) | PRKCAMMP12KDM2BSCN9AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |