Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 4/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.32 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12427972 | 0.96 | PRKCA (0.42) | PRKCAMMP12CNR1SCN9ACYP3A4 | |
| SCHEMBL12427926 | 0.91 | PRKCA (0.41) | PRKCAMMP12SCN9ACYP3A4NR1I2 | |
| SCHEMBL12428329 | 0.91 | PRKCA (0.41) | PRKCAMMP12SCN9ANR1I2MCL1 | |
| SCHEMBL12427977 | 0.91 | PRKCA (0.41) | PRKCAMMP12CNR1SCN9ACYP3A4 | |
| SCHEMBL12428477 | 0.90 | PRKCA (0.41) | PRKCAMMP12SCN9ACYP3A4KCNH2 | |
| SCHEMBL12428529 | 0.89 | PRKCA (0.40) | PRKCAMMP12SCN9AKCNH2NR1I2 | |
| SCHEMBL12428150 | 0.89 | PRKCA (0.42) | PRKCAMMP12CNR1SCN9ACYP3A4 | |
| SCHEMBL12427956 | 0.89 | PRKCA (0.42) | PRKCAMMP12CNR1SCN9ACYP3A4 | |
| SCHEMBL12428144 | 0.89 | PRKCA (0.42) | PRKCAMMP12CNR1SCN9ACYP3A4 | |
| SCHEMBL12427974 | 0.89 | PRKCA (0.41) | PRKCAMMP12SCN9ACYP3A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |