Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | RARB | P10826 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1747963 | 0.96 | AR (0.45) | ARMAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL5006829 | 0.84 | NPC1 (0.42) | ARMAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL5003331 | 0.78 | POLB (0.39) | ARMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL1748072 | 0.77 | AR (0.45) | ARMAPTALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL18065664 | 0.73 | ALDH1A1 (0.49) | MAPTALDH1A1SMN1; SMN2TAAR1POLB | |
| SCHEMBL6650516 | 0.73 | GSK3B (0.44) | MAPTALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL12430069 | 0.73 | NPSR1 (0.45) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7613025 | 0.72 | ALDH1A1 (0.46) | MAPTALDH1A1SMN1; SMN2TAAR1 | |
| SCHEMBL7139929 | 0.72 | ALDH1A1 (0.49) | ARALDH1A1SMN1; SMN2RAB9ALMNA | |
| SCHEMBL7614875 | 0.71 | ALDH1A1 (0.45) | MAPTALDH1A1SMN1; SMN2TAAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633722-B1 | PREPARATION AND USE OF ARYL ALKYL ACID DERIVATIVES FOR THE TREATMENT OF OBESITY | BAYER HEALTHCARE LLC (US) | 2011-08-03 | — | — | EP | disclosed |