Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2395007 | 0.88 | MAPT (0.48) | NPC1RAB9ASMN1; SMN2TAAR1AR | |
| SCHEMBL5006828 | 0.86 | RARB (0.41) | NPC1RAB9ASMN1; SMN2RARB | |
| SCHEMBL12428576 | 0.84 | AR (0.44) | NPC1RAB9ASMN1; SMN2TAAR1LMNA | |
| SCHEMBL1747963 | 0.83 | AR (0.45) | NPC1RAB9ASMN1; SMN2TAAR1LMNA | |
| SCHEMBL5003331 | 0.77 | POLB (0.39) | SMN1; SMN2LMNAARPOLBMAPK1 | |
| SCHEMBL5006820 | 0.75 | MAPK1 (0.46) | POLBMAPK1MAPTALDH1A1KMT2A | |
| SCHEMBL1748072 | 0.74 | AR (0.45) | NPC1RAB9ASMN1; SMN2TAAR1LMNA | |
| SCHEMBL5007313 | 0.72 | SMN1; SMN2 (0.42) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL5009259 | 0.72 | POLB (0.42) | NPC1RAB9ASMN1; SMN2POLBMAPK1 | |
| SCHEMBL1748173 | 0.71 | GSK3B (0.58) | SMN1; SMN2POLBMAPK1MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423156-B2 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER PHARMACEUTICALS CORPORATION (US) | 2008-09-09 | — | — | US | disclosed |