Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL771585 | 0.99 | ALDH1A1 (0.40) | ALDH1A1HPGDNPC1USP2MAPT | |
| SCHEMBL10283206 | 0.92 | PRKCA (0.41) | ALDH1A1HPGDMAPTPRKCAMMP12 | |
| SCHEMBL12428586 | 0.91 | PRKCA (0.43) | ALDH1A1HPGDMAPTPRKCAMMP12 | |
| Hydrochloric Acid SCHEMBL773981 | 0.91 | PRKCA (0.40) | ALDH1A1HPGDMAPTPRKCAMMP12 | |
| Hydrochloric Acid SCHEMBL771474 | 0.91 | PRKCA (0.43) | ALDH1A1HPGDMAPTPRKCAMMP12 | |
| SCHEMBL12428587 | 0.88 | PRKCA (0.40) | ALDH1A1USP2MAPTPRKCAMMP12 | |
| Hydrochloric Acid SCHEMBL771450 | 0.88 | PRKCA (0.40) | ALDH1A1USP2MAPTPRKCAMMP12 | |
| SCHEMBL10283208 | 0.87 | PRKCA (0.41) | L3MBTL1PRKCAMMP12KDM4EMEN1 | |
| SCHEMBL12428594 | 0.86 | PRKCA (0.43) | PRKCAMMP12HRH3SCN9A | |
| SCHEMBL10283204 | 0.86 | PRKCA (0.46) | ALDH1A1HPGDNPC1PRKCAMMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |