Nisoxetine

Nisoxetine

SCHEMBL124289

CNCCC(Oc1ccccc1OC)c1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 13/20 1.00
SLC6A2 P23975 10/20 1.00
CYP2D6 P10635 5/20 1.00
CYP1A2 P05177 4/20 1.00
CYP3A4 P08684 4/20 1.00
TSHR P16473 3/20 1.00
SLC6A3 Q01959 3/20 1.00
KMT2A Q03164 2/20 1.00
MEN1 O00255 1/20 1.00
CYP2C19 P33261 1/20 1.00
PMP22 Q01453 2/20 0.97
CHRM1 P11229 2/20 0.73
ADRA2B P18089 2/20 0.73
HTR2A P28223 2/20 0.73
HTR2C P28335 2/20 0.73
HRH1 P35367 2/20 0.73
OPRM1 P35372 2/20 0.73
DRD3 P35462 2/20 0.73
OPRK1 P41145 2/20 0.73
HTR2B P41595 2/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nisoxetine SCHEMBL30026153 1.00 SLC6A4 (1.00) SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4
Nisoxetine SCHEMBL29401038 1.00 SLC6A4 (1.00) SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4
Nisoxetine SCHEMBL3897550 1.00 SLC6A4 (1.00) SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4
Nisoxetine SCHEMBL3892886 1.00 SLC6A4 (1.00) SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4
Nisoxetine SCHEMBL29440249 0.98 SLC6A2 (1.00) SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4
Nisoxetine SCHEMBL467262 0.98 SLC6A2 (1.00) SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4
Nisoxetine SCHEMBL14973458 0.97 SLC6A4 (0.94) SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4
Nisoxetine SCHEMBL4083146 0.93 SLC6A4 (0.86) SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4
[3H]Nisoxetine SCHEMBL29463855 0.90 SLC6A2 (1.00) SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4
SCHEMBL5309993 0.86 SLC6A2 (0.76) SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2534 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260083709-A1 COMBINATION PHARMACOLOGICAL INTERVENTIONS FOR MULTIPLE MECHANISMS OF OBSTRUCTIVE SLEEP APNEA APNIMED INC DELAWARE (US) 2026-03-26 US claimed
EP-4704971-A1 GAMMA STIMULATION AND NEUROMODULATOR COMBINATION THERAPY Cognito Therapeutics, Inc. (US) 2026-03-11 EP claimed
EP-4704826-A1 COMPOSITIONS AND METHODS FOR TREATING POST-TRAUMATIC STRESS DISORDER Yale University (US) 2026-03-11 EP claimed
US-20260027070-A1 METHODS AND COMPOSITIONS FOR TREATING SLEEP APNEA APNIMED INC DELAWARE (US) 2026-01-29 US claimed
US-20250325510-A1 METHODS AND COMPOSITIONS FOR TREATING SLEEP APNEA APRIMED INC DELAWARE (US) 2025-10-23 US claimed
EP-4635514-A2 METHODS AND COMPOSITIONS FOR TREATING SLEEP APNEA The Brigham & Women's Hospital, Inc. (US) 2025-10-22 EP claimed
WO-2025151884-A1 USE OF GLYCOSAMINOGLYCAN SULFATED POLYSACCHARIDES SUCH AS SODIUM PENTOSAN POLYSULFATE IN COMBINATION WITH PERMEATION AGENTS TO TREAT ALZHEIMER'S DISEASE PARSONS C LOWELL (US) 2025-07-17 WO claimed
US-20250186371-A1 METHODS AND COMPOSITIONS FOR TREATING SLEEP APNEA APNIMED, INC. (DELAWARE) 2025-06-12 US claimed
US-20250114321-A1 METHODS AND COMPOSITIONS FOR TREATING SLEEP APNEA APNIMED, INC. (DELAWARE) 2025-04-10 US claimed
CN-119789855-A Methods and compositions for treating sleep apnea 爱普宁公司(特拉华) 2025-04-08 CN claimed
US-20030130355-A1 Therapeutic agents KNOLL GMBH (DE) 2003-07-10 US claimed
EP-1308435-A2 Process for producing optically active amino alcohols Kanto Kagaku Kabushiki Kaisha (JP) 2003-05-07 EP claimed
EP-0831799-B1 COMPOUNDS ACTIVE AT A NOVEL SITE ON RECEPTOR-OPERATED CALCIUM CHANNELS USEFUL FOR TREATMENT OF NEUROLOGICAL DISORDERS NPS PHARMA INC (US) 2003-05-02 EP claimed
EP-1259292-A2 THERAPEUTIC AGENTS Knoll GmbH (DE) 2002-11-27 EP claimed
US-20020161002-A1 Norepinephrine reuptake inhibitors; to increase memory function such as long-term memory and recall ability SENTION, INC. 2002-10-31 US claimed
WO-2002053104-A2 USE OF CATECHOLAMINE REUPTAKE INHIBITORS TO ENHANCE MEMORY SENTION, INC. (US) 2002-07-11 WO claimed
WO-2002043652-A2 ANTI-PROLIFERATIVE DRUGS RAMOT AT TEL-AVIV UNIVERSITY LTD. (IL) 2002-06-06 WO claimed
WO-2001062341-A2 COMBINATION PRODUCT FOR THE TREATMENT OF OBESITY KNOLL GMBH (DE) 2001-08-30 WO claimed
WO-1997041878-A1 TREATMENT OF MOOD DISORDERS WITH A GROWTH HORMONE SECRETAGOGUE MERCK & CO., INC. (US) 1997-11-13 WO claimed
EP-0174342-B1 BRAIN-SPECIFIC ANALOGUES OF CENTRALLY ACTING AMINES UNIVERSITY OF FLORIDA (US) 1989-12-20 EP claimed