Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 13/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 10/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 5/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 4/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 4/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.73 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.73 |
| ▸ | HTR2A | P28223 | 2/20 | 0.73 |
| ▸ | HTR2C | P28335 | 2/20 | 0.73 |
| ▸ | HRH1 | P35367 | 2/20 | 0.73 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.73 |
| ▸ | DRD3 | P35462 | 2/20 | 0.73 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.73 |
| ▸ | HTR2B | P41595 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nisoxetine SCHEMBL30026153 | 1.00 | SLC6A4 (1.00) | SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4 | |
| Nisoxetine SCHEMBL124289 | 1.00 | SLC6A4 (1.00) | SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4 | |
| Nisoxetine SCHEMBL3892886 | 1.00 | SLC6A4 (1.00) | SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4 | |
| Nisoxetine SCHEMBL3897550 | 1.00 | SLC6A4 (1.00) | SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4 | |
| Nisoxetine SCHEMBL29440249 | 0.98 | SLC6A2 (1.00) | SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4 | |
| Nisoxetine SCHEMBL467262 | 0.98 | SLC6A2 (1.00) | SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4 | |
| Nisoxetine SCHEMBL14973458 | 0.97 | SLC6A4 (0.94) | SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4 | |
| Nisoxetine SCHEMBL4083146 | 0.93 | SLC6A4 (0.86) | SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4 | |
| [3H]Nisoxetine SCHEMBL29463855 | 0.90 | SLC6A2 (1.00) | SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL8971814 | 0.86 | SLC6A2 (0.76) | SLC6A4SLC6A2CYP2D6CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118021970-A | Antagonists of the complement system for methods of treating paraproteinemic neuropathy | 阿尔金克斯有限公司 | 2024-05-14 | — | — | CN | claimed |
| EP-4706683-A2 | CHEWABLE FORMULATIONS | Elanco Tiergesundheit AG (CH) | 2026-03-11 | — | — | EP | disclosed |
| CN-119950749-A | Polymer-based macromolecular prodrugs | 费城儿童医院 | 2025-05-09 | — | — | CN | disclosed |
| CN-119789855-A | Methods and compositions for treating sleep apnea | 爱普宁公司(特拉华) | 2025-04-08 | — | — | CN | disclosed |
| CN-119403548-A | Method of treating sleep apnea with a combination of cannabinoid and carbonic anhydrase inhibitors | 爱普宁公司(特拉华) | 2025-02-07 | — | — | CN | disclosed |
| CN-112996533-B | Polymer-based macromolecular prodrugs | 费城儿童医院 | 2025-01-10 | — | — | CN | disclosed |
| CN-118973577-A | Apostistin for the treatment of multiple system atrophy | 施万生物制药研发IP有限责任公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-118702908-A | Sulfur-containing polyethylene glycol derivative, preparation method thereof and application thereof in selective oxidation of alcoholic hydroxyl group | 陕西师范大学 | 2024-09-27 | — | — | CN | disclosed |
| CN-118702908-A | Sulfur-containing polyethylene glycol derivative, preparation method thereof and application thereof in selective oxidation of alcoholic hydroxyl group | 陕西师范大学 | 2024-09-27 | — | — | CN | disclosed |
| CN-116217415-B | Method for synthesizing chiral 3-amino-1-phenylpropanol and chiral 3- (methylamino) -1-phenylpropanol | 武汉大学 | 2024-06-18 | — | — | CN | disclosed |
| CN-111848577-B | N- (hetero) aryl-substituted heterocyclic derivatives useful in the treatment of diseases or conditions associated with the central nervous system | 克罗诺斯治疗有限公司 | 2023-09-01 | — | — | CN | disclosed |
| EP-4208155-A1 | CHEWABLE FORMULATIONS | Elanco Tiergesundheit AG (CH) | 2023-07-12 | — | — | EP | disclosed |
| CN-116217413-A | Synthesis method of key intermediate N-methyl-3-hydroxyamphetamine | 山东新时代药业有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-116217414-A | Preparation method of N-methyl-3-hydroxyamphetamine | 山东新时代药业有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-116217415-A | Method for synthesizing chiral 3-amino-1-phenylpropanol and chiral 3- (methylamino) -1-phenylpropanol | 武汉大学 | 2023-06-06 | — | — | CN | disclosed |
| CN-115768781-A | 3. Alpha, hydroxy, 17, beta, C (O) -N-aryl substituted neuroactive steroids and compositions thereof | 萨奇治疗股份有限公司 | 2023-03-07 | — | — | CN | disclosed |
| US-11490856-B2 | Method and a system for analyzing neuropharmacology of a drug | CITY UNIVERSITY OF HONG KONG (HK) | 2022-11-08 | — | — | US | disclosed |
| CN-115190815-A | Arylcyclohexylamine derivatives and their use in the treatment of psychotic disorders | 吉尔伽美什制药公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-114206900-A | Neuroactive steroids and compositions thereof | 萨奇治疗股份有限公司 | 2022-03-18 | — | — | CN | disclosed |
| WO-2022049149-A1 | CHEWABLE FORMULATIONS | ELANCO TIERGESUNDHEIT AG (CH) | 2022-03-10 | — | — | WO | disclosed |