Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 13/20 | 0.76 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.76 |
| ▸ | TSHR | P16473 | 3/20 | 0.76 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.76 |
| ▸ | MEN1 | O00255 | 1/20 | 0.76 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.76 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.74 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.55 |
| ▸ | HRH1 | P35367 | 2/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.55 |
| ▸ | DRD3 | P35462 | 2/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.55 |
| ▸ | HTR2B | P41595 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nisoxetine SCHEMBL30026153 | 0.86 | SLC6A4 (1.00) | SLC6A2SLC6A4CYP2D6CYP1A2CYP3A4 | |
| Nisoxetine SCHEMBL3897550 | 0.86 | SLC6A4 (1.00) | SLC6A2SLC6A4CYP2D6CYP1A2CYP3A4 | |
| Nisoxetine SCHEMBL124289 | 0.86 | SLC6A4 (1.00) | SLC6A2SLC6A4CYP2D6CYP1A2CYP3A4 | |
| Nisoxetine SCHEMBL3892886 | 0.86 | SLC6A4 (1.00) | SLC6A2SLC6A4CYP2D6CYP1A2CYP3A4 | |
| Nisoxetine SCHEMBL29401038 | 0.86 | SLC6A4 (1.00) | SLC6A2SLC6A4CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL8971047 | 0.85 | SLC6A4 (0.76) | SLC6A2SLC6A4CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL5309993 | 0.85 | SLC6A2 (0.76) | SLC6A2SLC6A4CYP2D6CYP1A2CYP3A4 | |
| Nisoxetine SCHEMBL467262 | 0.85 | SLC6A2 (1.00) | SLC6A2SLC6A4CYP2D6CYP1A2CYP3A4 | |
| Nisoxetine SCHEMBL29440249 | 0.85 | SLC6A2 (1.00) | SLC6A2SLC6A4CYP2D6CYP1A2CYP3A4 | |
| Nisoxetine SCHEMBL14973458 | 0.84 | SLC6A4 (0.94) | SLC6A2SLC6A4CYP2D6CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0545425-B1 | 2-(3-Phenylpropyl)hydrazines, intermediates in and a process for the preparation thereof, and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-03-20 | — | — | EP | disclosed |
| US-5268468-A | Or optical isomers thereof | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-12-07 | — | — | US | disclosed |
| US-5229417-A | Obsessive compulsive disorders | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-07-20 | — | — | US | disclosed |
| EP-0545425-A1 | 2-(3-Phenylpropyl)hydrazines, intermediates in and a process for the preparation thereof, and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-06-09 | — | — | EP | disclosed |