Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 13/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1027734 | 0.94 | KIF11 (0.44) | KIF11MAPK1CA9ALDH1A1MAPT | |
| SCHEMBL30100755 | 0.94 | KIF11 (0.44) | KIF11MAPK1CA9ALDH1A1MAPT | |
| SCHEMBL12428933 | 0.81 | KIF11 (0.44) | KIF11MAPK1CA9ALDH1A1MAPT | |
| SCHEMBL2206012 | 0.81 | CYP11B1 (0.45) | KIF11CA9ALDH1A1MAPTPKM | |
| SCHEMBL5502745 | 0.79 | PGR (0.46) | ALDH1A1MAPTPKM | |
| SCHEMBL25387325 | 0.78 | CYP11B1 (0.47) | KIF11MAPK1CA9ALDH1A1MAPT | |
| SCHEMBL20594837 | 0.78 | MAPT (0.55) | KIF11MAPK1CA9ALDH1A1MAPT | |
| SCHEMBL21646065 | 0.78 | KIF11 (0.44) | KIF11CA9PKMCYP11B1CYP11B2 | |
| SCHEMBL30100717 | 0.78 | KIF11 (0.44) | KIF11MAPK1CA9ALDH1A1PKM | |
| SCHEMBL23674943 | 0.78 | KIF11 (0.44) | KIF11MAPK1CA9ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981903-B2 | 2-[2-{phenylamino}-1H-pyrrolo[2,3-D]pyrimidin-4-yl)amino] benzamide derivatives as IGF-1R inhibitors for the treatment of cancer | GLAXOSMITHKLINE LLC (US) | 2011-07-19 | — | — | US | disclosed |