Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL774451 | 0.92 | PRKCA (0.46) | PRKCAMMP12HTTNR1I2LMNA | |
| SCHEMBL773811 | 0.90 | PRKCA (0.44) | PRKCAMMP12HTTNR1I2LMNA | |
| SCHEMBL774322 | 0.89 | PRKCA (0.47) | PRKCAMMP12HTTNR1I2LMNA | |
| SCHEMBL12429031 | 0.86 | PRKCA (0.43) | PRKCAMMP12NR1I2SCN9AMAPT | |
| SCHEMBL774060 | 0.85 | PRKCA (0.48) | PRKCAMMP12HTTNR1I2LMNA | |
| SCHEMBL772489 | 0.81 | ROCK2 (0.48) | PRKCAMMP12NR1I2KMT2ASCN9A | |
| SCHEMBL12429016 | 0.81 | PRKCA (0.43) | PRKCAMMP12NR1I2SCN9AMAPT | |
| SCHEMBL771736 | 0.80 | PRKCA (0.48) | PRKCAMMP12NR1I2SCN9ATP53 | |
| SCHEMBL773991 | 0.80 | PRKCA (0.46) | PRKCAMMP12NR1I2SCN9A | |
| SCHEMBL774557 | 0.79 | PRKCA (0.54) | PRKCAMMP12HTTNR1I2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |
| US-7977331-B1 | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor | JAPAN TOBACCO INC. (JP) | 2011-07-12 | — | — | US | disclosed |