SCHEMBL12430541

SCHEMBL12430541

CNC(CCC(C)C)c1cc(C(=O)N2Cc3ccccc3C2)ccc1C

nearest known ligand 0.54

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 13/20 0.54
HSP90AB1 P08238 9/20 0.54
TRAP1 Q12931 2/20 0.44
HSP90B1 P14625 2/20 0.43
NAMPT P43490 2/20 0.43
LMNA P02545 1/20 0.42
RECQL P46063 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
ACACB O00763 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14232145 0.81 HSP90AA1 (0.75) HSP90AA1HSP90AB1TRAP1HSP90B1
SCHEMBL383219 0.71 HSP90AA1 (1.00) HSP90AA1HSP90AB1TRAP1HSP90B1
SCHEMBL383080 0.70 HSP90AA1 (0.78) HSP90AA1HSP90AB1TRAP1HSP90B1
SCHEMBL3417055 0.70 TRAP1 (0.56) HSP90AA1HSP90AB1TRAP1HSP90B1NAMPT
SCHEMBL13983957 0.67 HSP90AB1 (0.45) HSP90AA1HSP90AB1TRAP1HSP90B1NAMPT
SCHEMBL3455489 0.67 HPGD (0.65) HSP90AA1HSP90AB1NAMPTLMNARECQL
SCHEMBL382768 0.66 HSP90AA1 (1.00) HSP90AA1HSP90AB1TRAP1HSP90B1NAMPT
SCHEMBL31047689 0.66 PKM (0.62) HSP90AA1HSP90AB1TRAP1HSP90B1NAMPT
SCHEMBL17618301 0.66 TRAP1 (0.65) HSP90AA1HSP90AB1TRAP1HSP90B1NAMPT
SCHEMBL12569373 0.65 HPGD (0.64) HSP90AA1HSP90AB1TRAP1HSP90B1NAMPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2155690-B1 INDAZOLAMIDE DERIVATIVES MERCK PATENT GMBH (DE) 2011-08-03 EP disclosed