Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.33 |
| ▸ | GPR55 | Q9Y2T6 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.31 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 2/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8059930 | 0.79 | MAPT (0.39) | TAAR1AMY1ACYP1A2CYP2A6ALDH1A1 | |
| SCHEMBL233314 | 0.78 | TAAR1 (0.41) | TAAR1AMY1ACYP1A2CYP2A6ALDH1A1 | |
| SCHEMBL21768182 | 0.77 | NPSR1 (0.43) | TAAR1AMY1ACYP1A2CYP2A6ALDH1A1 | |
| SCHEMBL30574669 | 0.77 | TAAR1 (0.38) | TAAR1AMY1ACYP1A2CYP2A6ALDH1A1 | |
| SCHEMBL6036585 | 0.77 | AMY1A (0.39) | TAAR1AMY1ACYP1A2CYP2A6ALDH1A1 | |
| SCHEMBL26586480 | 0.77 | TAAR1 (0.38) | TAAR1AMY1ACYP1A2CYP2A6ALDH1A1 | |
| SCHEMBL1050239 | 0.76 | TAAR1 (0.56) | TAAR1AMY1ACYP1A2CYP2A6ALDH1A1 | |
| SCHEMBL30087221 | 0.74 | CYP2A6 (0.32) | CYP1A2CYP2A6ALDH1A1TDP1CYP3A4 | |
| SCHEMBL30806439 | 0.74 | TAAR1 (0.39) | TAAR1AMY1ACYP1A2CYP2A6ALDH1A1 | |
| SCHEMBL2556376 | 0.74 | CYP2A6 (0.32) | CYP1A2CYP2A6ALDH1A1TDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160075724-A1 | CETP Inhibitors | MERCK SHARP & DOHME (US) | 2016-03-17 | — | — | US | disclosed |
| US-20140221383-A1 | CETP INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-08-07 | — | — | US | disclosed |
| US-8440702-B2 | 1,3-oxazolidin -2-one derivatives useful as CETP inhibitors | MERCK SHARP & DOHME CORP. (US) | 2013-05-14 | — | — | US | disclosed |
| US-20110178059-A1 | 1,3-OXAZOLIDIN -2-ONE DERIVATIVES USEFUL AS CETP INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221383-A1 | CETP INHIBITORS | CETP, APOB, MTTP | TAAR1 2358/4885AMY1A 2606/4885CYP1A2 545/4885 |
| US-20110178059-A1 | 1,3-OXAZOLIDIN -2-ONE DERIVATIVES USEFUL AS CETP INHIBITORS | CETP, MTTP, APOB | TAAR1 3197/4885AMY1A 2903/4885CYP1A2 2013/4885 |
| US-20160075724-A1 | CETP Inhibitors | CETP, APOB, MTTP | TAAR1 2358/4885AMY1A 2606/4885CYP1A2 545/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.