Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.42 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.42 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.37 |
| ▸ | PIP4K2A | P48426 | 2/20 | 0.37 |
| ▸ | PIP4K2B | P78356 | 2/20 | 0.37 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.36 |
| ▸ | CDK9 | P50750 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | FADS1 | O60427 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL1242107 | 0.94 | PTGS1 (0.40) | PTGS1PIP4K2CP2RX1NPSR1MAPT | |
| SCHEMBL1244549 | 0.94 | PIP4K2C (0.46) | PTGS1PIP4K2CPIP4K2APIP4K2BPIKFYVE | |
| Trifluoroacetic Acid SCHEMBL1242021 | 0.89 | PIP4K2C (0.49) | PTGS1PIP4K2CPIP4K2APIP4K2BPIKFYVE | |
| SCHEMBL1244828 | 0.88 | PIP4K2C (0.42) | PTGS1PIP4K2CPIP4K2APIP4K2BPIKFYVE | |
| Trifluoroacetic Acid SCHEMBL1242168 | 0.88 | PIP4K2C (0.45) | PTGS1PIP4K2CPIP4K2APIP4K2BPIKFYVE | |
| Trifluoroacetic Acid SCHEMBL1244577 | 0.87 | ALDH1A1 (0.40) | PIP4K2CMAPTKDM4EHPGDCCNT1 | |
| Trifluoroacetic Acid SCHEMBL1243926 | 0.86 | PIP4K2C (0.48) | PIP4K2CPIP4K2APIP4K2BPIKFYVENPSR1 | |
| Trifluoroacetic Acid SCHEMBL1242277 | 0.85 | PIP4K2C (0.43) | PIP4K2CPIP4K2APIP4K2BPIKFYVENPSR1 | |
| SCHEMBL1244414 | 0.84 | PIP4K2C (0.46) | PIP4K2CPIP4K2APIP4K2BPIKFYVENPSR1 | |
| Trifluoroacetic Acid SCHEMBL1244417 | 0.84 | PIP4K2C (0.46) | PIP4K2CPIP4K2APIP4K2BPIKFYVENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879853-B2 | tyrosisne kinase inhibitors such as N-[4-(6-Dibenzofuran-4-yl-pyrimidin-4-ylamino)-phenyl]-4-morpholin-4-yl-benzamide, used as anticasrcinogenic or antoproliferative agents, especially in the treatment of breast cancer | BAYER SCHERING PHARMA AG (DE) | 2011-02-01 | — | — | US | disclosed |
| EP-1763526-B1 | 4,6-DISUBSTITUTED PYRIMIDINES AND THEIR USE AS PROTEIN KINASE INHIBITORS | BAYER SCHERING PHARMA AG (DE) | 2009-06-24 | — | — | EP | disclosed |
| US-20070208034-A1 | 4,6-disubstituted pyrimidines and their use as protein kinase inhibitors | ATLANTA PHARMA AG (DE) | 2007-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070208034-A1 | 4,6-disubstituted pyrimidines and their use as protein kinase inhibitors | CDK2, DCK, DTYMK | PTGS1 2191/4885PIP4K2C 52/4885P2RX1 1195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.