Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.68 |
| ▸ | SYK | P43405 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | LTA4H | P09960 | 3/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.45 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6314286 | 0.89 | SYK (0.56) | POLBSYKMEN1KMT2AALDH1A1 | |
| SCHEMBL12435658 | 0.87 | SYK (0.77) | POLBSYKMEN1KMT2ACYP2D6 | |
| SCHEMBL1929865 | 0.82 | HTR2C (0.58) | POLBLTA4HPTGS1PTGS2SMN1; SMN2 | |
| SCHEMBL264641 | 0.82 | LTA4H (0.62) | POLBLTA4HPTGS1PTGS2SMN1; SMN2 | |
| SCHEMBL6996167 | 0.81 | ALDH1A1 (0.55) | POLBMEN1KMT2AALDH1A1LTA4H | |
| SCHEMBL5474831 | 0.81 | HTR2C (0.60) | POLBLTA4HSMN1; SMN2HTR2AHTR2C | |
| SCHEMBL4042949 | 0.81 | SLC29A1 (0.50) | POLBSYKMEN1KMT2ACYP2D6 | |
| SCHEMBL31378713 | 0.81 | LTA4H (0.61) | POLBLTA4HPTGS1PTGS2SMN1; SMN2 | |
| SCHEMBL4267515 | 0.81 | LTA4H (0.61) | POLBLTA4HPTGS1PTGS2SMN1; SMN2 | |
| SCHEMBL4023281 | 0.81 | HTR2C (0.60) | POLBLTA4HSMN1; SMN2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0989985-B1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 2003-11-05 | — | — | EP | disclosed |
| US-6133257-A | Fused polycyclic 2-aminopyrimidine derivatives | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-10-17 | — | — | US | disclosed |
| EP-0989985-A1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 2000-04-05 | — | — | EP | disclosed |
| WO-1998058926-A1 | FUSED POLYCYCLIC 2-AMINOPYRIMIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | CELLTECH THERAPEUTICS LIMITED (GB) | 1998-12-30 | — | — | WO | disclosed |