Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | TP53 | P04637 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | PLAU | P00749 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | PLG | P00747 | 1/20 | 0.52 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17507497 | 0.83 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL12428708 | 0.81 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL31680508 | 0.78 | NPC1 (0.93) | NPC1RAB9ASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL29244714 | 0.77 | ALDH1A1 (0.52) | NPC1RAB9ASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL4248077 | 0.75 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL29420092 | 0.72 | NPC1 (0.81) | NPC1RAB9ASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL1918108 | 0.72 | NPC1 (0.81) | NPC1RAB9ASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL12429013 | 0.72 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL12218147 | 0.71 | RAB9A (0.79) | NPC1RAB9ASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL28187512 | 0.70 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110178108-A1 | Group of amino substituted benzoyl derivatives and their preparation and their use | Institute of Medicinal Biotechnology Academy of Medical Science (CN) | 2011-07-21 | — | — | US | disclosed |
| US-20110178108-A1 | Group of amino substituted benzoyl derivatives and their preparation and their use | Institute of Medicinal Biotechnology Academy of Medical Science (CN) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178108-A1 | Group of amino substituted benzoyl derivatives and their preparation and their use | CUL3, APOBEC3G, BRPF3 | NPC1 3314/4885RAB9A 1374/4885SMN1; SMN2 4598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.