Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 13/20 | 0.55 |
| ▸ | RAB9A | P51151 | 13/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.55 |
| ▸ | TP53 | P04637 | 4/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12436031 | 0.89 | MAPK1 (0.57) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL17507496 | 0.86 | HDAC8 (0.62) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL12435922 | 0.84 | ATM (0.51) | SMN1; SMN2TP53ALDH1A1MAPTKMT2A | |
| SCHEMBL12435942 | 0.83 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL12435950 | 0.82 | NPC1 (0.56) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL12435959 | 0.81 | ATM (0.47) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL12429013 | 0.79 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2TP53ALOX15 | |
| SCHEMBL12435970 | 0.79 | TRPV1 (0.54) | NPC1RAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL12435951 | 0.77 | RXFP1 (0.60) | NPC1RAB9ASMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL27641819 | 0.76 | L3MBTL1 (0.69) | NPC1RAB9ASMN1; SMN2TP53ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110178108-A1 | Group of amino substituted benzoyl derivatives and their preparation and their use | Institute of Medicinal Biotechnology Academy of Medical Science (CN) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178108-A1 | Group of amino substituted benzoyl derivatives and their preparation and their use | CUL3, APOBEC3G, BRPF3 | NPC1 3314/4885RAB9A 1374/4885SMN1; SMN2 4598/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.