Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | STAT3 | P40763 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4116093 | 0.88 | FOXO1 (0.48) | LMNAKMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL25069803 | 0.87 | KMT2A (0.48) | LMNAKMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL1242688 | 0.87 | KMT2A (0.50) | LMNAKMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL1242783 | 0.85 | LMNA (0.55) | LMNAKMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL1243138 | 0.84 | LMNA (0.46) | LMNAKMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL8112020 | 0.83 | KDM4E (0.54) | LMNAKMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL25069717 | 0.83 | KMT2A (0.47) | LMNAKMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL1243960 | 0.81 | KMT2A (0.51) | LMNAKMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL1243131 | 0.81 | KMT2A (0.50) | LMNAKMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL1242619 | 0.80 | FOXO1 (0.57) | LMNAKMT2AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879878-B2 | such as {2-[({[7-(cyclohexylamino)-6-fluoro-4-oxo-1-[(3S)-tetrahydrofuran-3-yl]-1,4-dihydroquinolin-3-yl}carbonyl)amino]ethyl}phosphonic acid, used as platelet aggregation inhibitor and purinergic receptor (P2Y12) inhibitors; therapy for circulatory diseases involving thrombosis via platelet aggregation | ASTELLAS PHARMA INC. (JP) | 2011-02-01 | — | — | US | disclosed |