Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ACACB | O00763 | 8/20 | 0.36 |
| ▸ | FURIN | P09958 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12436997 | 0.92 | THRB (0.41) | THRBTSHRHPGDALDH1A1CYP3A4 | |
| SCHEMBL15852957 | 0.89 | PRSS1 (0.44) | THRBTSHRHPGDALDH1A1CYP3A4 | |
| SCHEMBL25500952 | 0.89 | THRB (0.49) | THRBTSHRHPGDALDH1A1CYP3A4 | |
| SCHEMBL14907529 | 0.88 | THRB (0.59) | THRBTSHRHPGDALDH1A1CYP3A4 | |
| SCHEMBL18200235 | 0.88 | THRB (0.59) | THRBTSHRHPGDALDH1A1CYP3A4 | |
| SCHEMBL18200264 | 0.88 | THRB (0.48) | THRBTSHRHPGDALDH1A1CYP3A4 | |
| SCHEMBL14373547 | 0.85 | THRB (0.59) | THRBTSHRHPGDALDH1A1CYP3A4 | |
| SCHEMBL12348188 | 0.85 | THRB (0.59) | THRBTSHRHPGDALDH1A1CYP3A4 | |
| SCHEMBL12604080 | 0.84 | TSHR (0.59) | THRBTSHRHPGDALDH1A1CYP3A4 | |
| SCHEMBL14373542 | 0.83 | THRB (0.65) | THRBTSHRHPGDALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455563-B2 | Reactive mesogenic compounds and mixtures | MERCK PATENT GMBH (DE) | 2013-06-04 | — | — | US | disclosed |
| US-20110178200-A1 | REACTIVE MESOGENIC COMPOUNDS AND MIXTURES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178200-A1 | REACTIVE MESOGENIC COMPOUNDS AND MIXTURES | BLM, MITF, PARG | THRB 4861/4885TSHR 4541/4885HPGD 3773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.