Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | ACP3 | P15309 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28358062 | 0.82 | TDP1 (0.66) | TDP1CYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL29420689 | 0.80 | TDP1 (0.69) | TDP1CYP1A2CYP2C19CYP2C9ACP3 | |
| SCHEMBL1019076 | 0.80 | TDP1 (0.69) | TDP1CYP1A2CYP2C19CYP2C9ACP3 | |
| SCHEMBL6027916 | 0.80 | TDP1 (0.58) | TDP1CYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL4685576 | 0.77 | TDP1 (0.55) | TDP1CYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL9014822 | 0.77 | APOBEC3G (0.41) | TDP1L3MBTL1HPGDLMNA | |
| SCHEMBL17435206 | 0.77 | TDP1 (0.70) | TDP1CYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL3167336 | 0.76 | TDP1 (0.69) | TDP1CYP1A2CYP2C19CYP2C9ACP3 | |
| SCHEMBL14351647 | 0.76 | TDP1 (0.58) | TDP1CYP1A2CYP2C19CYP2D6CYP2C9 | |
| SCHEMBL13751485 | 0.76 | ATM (0.56) | TDP1CYP1A2CYP2C19CYP2D6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011094628-A1 | COMPOSITIONS AND METHODS FOR TREATING TOXOPLASMOSIS. CRYPTOSPORIDIOSIS AND OTHER APICOMPLEXAN PROTOZOAN RELATED DISEASES | UNIVERSITY OF WASHINGTON (US) | 2011-08-04 | — | — | WO | disclosed |