Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 17/20 | 0.55 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | RET | P07949 | 2/20 | 0.40 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.40 |
| ▸ | STK10 | O94804 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | YES1 | P07947 | 1/20 | 0.40 |
| ▸ | LYN | P07948 | 1/20 | 0.40 |
| ▸ | HCK | P08631 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14050704 | 0.85 | IGF1R (0.48) | IGF1RAURKARETBMPR1BPLK4 | |
| SCHEMBL11347992 | 0.82 | IGF1R (0.80) | IGF1RAURKARETBMPR1BPLK4 | |
| SCHEMBL11415916 | 0.79 | IGF1R (0.69) | IGF1RAURKARETBMPR1BPLK4 | |
| SCHEMBL12439393 | 0.77 | IGF1R (0.49) | IGF1RAURKAAURKB | |
| SCHEMBL12439829 | 0.77 | IGF1R (0.52) | IGF1RAURKAAURKB | |
| SCHEMBL14310345 | 0.77 | IGF1R (0.44) | IGF1RAURKARETBMPR1BPLK4 | |
| SCHEMBL14162124 | 0.76 | IGF1R (0.49) | IGF1RAURKARETBMPR1BPLK4 | |
| SCHEMBL12438589 | 0.74 | IGF1R (0.50) | IGF1RAURKARETBMPR1BPLK4 | |
| SCHEMBL12439398 | 0.72 | IGF1R (0.53) | IGF1RABL1LCKFGFR1SRC | |
| SCHEMBL4464527 | 0.72 | IGF1R (0.74) | IGF1RAURKARETBMPR1BPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841760-B1 | PYRIMIDINE DERIVATIVES AS KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2011-08-10 | — | — | EP | disclosed |