Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 9/20 | 0.53 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 5/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | ROS1 | P08922 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14050575 | 0.92 | IGF1R (0.53) | IGF1RTNK2JAK2JAK3 | |
| SCHEMBL1787532 | 0.81 | IGF1R (0.78) | IGF1R | |
| SCHEMBL14161970 | 0.81 | IGF1R (0.48) | IGF1R | |
| SCHEMBL14320005 | 0.77 | IGF1R (0.52) | IGF1RHRH2HRH1HRH4HRH3 | |
| SCHEMBL12439393 | 0.76 | IGF1R (0.49) | IGF1RHRH2HRH1HRH4HRH3 | |
| SCHEMBL14320040 | 0.74 | IGF1R (0.49) | IGF1RTNK2JAK2JAK3CHEK1 | |
| SCHEMBL12439783 | 0.74 | IGF1R (0.51) | IGF1R | |
| SCHEMBL13234901 | 0.73 | IGF1R (0.66) | IGF1R | |
| SCHEMBL1793212 | 0.73 | IGF1R (0.78) | IGF1R | |
| SCHEMBL12438433 | 0.72 | IGF1R (0.55) | IGF1RTNK2SRCABL1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841760-B1 | PYRIMIDINE DERIVATIVES AS KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2011-08-10 | — | — | EP | disclosed |