Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 17/20 | 0.52 |
| ▸ | JAK3 | P52333 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4461457 | 0.81 | IGF1R (0.78) | IGF1R | |
| SCHEMBL14050575 | 0.78 | IGF1R (0.53) | IGF1RJAK3JAK2 | |
| SCHEMBL12438433 | 0.77 | IGF1R (0.55) | IGF1RAURKAAURKB | |
| SCHEMBL14050704 | 0.77 | IGF1R (0.48) | IGF1RAURKAAURKB | |
| SCHEMBL14311627 | 0.77 | IGF1R (0.51) | IGF1RJAK3JAK2AURKAAURKB | |
| SCHEMBL14310345 | 0.77 | IGF1R (0.44) | IGF1RAURKAAURKB | |
| SCHEMBL14310347 | 0.76 | IGF1R (0.46) | IGF1RJAK3JAK2AURKAAURKB | |
| SCHEMBL14320002 | 0.76 | IGF1R (0.49) | IGF1RJAK3JAK2AURKAAURKB | |
| SCHEMBL12439393 | 0.74 | IGF1R (0.49) | IGF1RAURKAAURKB | |
| SCHEMBL14050458 | 0.74 | IGF1R (0.48) | IGF1RJAK3JAK2AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841760-B1 | PYRIMIDINE DERIVATIVES AS KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2011-08-10 | — | — | EP | disclosed |
| WO-2008005538-A2 | METHODS OF USING IGF1R AND ABL KINASE MODULATORS | EXELIXIS, INC. (US) | 2008-01-10 | — | — | WO | disclosed |