Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 19/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12439773 | 0.85 | IGF1R (0.49) | IGF1RNTRK1CDK2NTRK2 | |
| SCHEMBL11343803 | 0.82 | IGF1R (0.70) | IGF1RNTRK1CDK2NTRK2 | |
| SCHEMBL11344519 | 0.80 | IGF1R (0.71) | IGF1RNTRK1CDK2NTRK2FGFR1 | |
| SCHEMBL12438231 | 0.79 | IGF1R (0.42) | IGF1R | |
| SCHEMBL14161970 | 0.79 | IGF1R (0.48) | IGF1RNTRK1 | |
| SCHEMBL11348777 | 0.79 | IGF1R (0.69) | IGF1RNTRK1 | |
| SCHEMBL12439842 | 0.79 | IGF1R (0.58) | IGF1RNTRK1CDK2NTRK2 | |
| SCHEMBL4462307 | 0.79 | IGF1R (0.58) | IGF1R | |
| SCHEMBL12427306 | 0.79 | IGF1R (0.58) | IGF1RNTRK1FGFR1KDR | |
| SCHEMBL11932346 | 0.78 | IGF1R (0.52) | IGF1RNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841760-B1 | PYRIMIDINE DERIVATIVES AS KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2011-08-10 | — | — | EP | disclosed |